58341

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 829558..830324 Replicon chromosome
Accession NZ_CP013312
Organism Vibrio cholerae strain E1320

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag ASZ88_RS18480 Protein ID WP_000982260.1
Coordinates 829558..830055 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag ASZ88_RS18485 Protein ID WP_000246253.1
Coordinates 830052..830324 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ88_RS18430 825420..825726 + 307 Protein_835 CatB-related O-acetyltransferase -
ASZ88_RS18435 825863..826555 + 693 WP_001047169.1 GNAT family N-acetyltransferase -
ASZ88_RS18440 826555..826956 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
ASZ88_RS20885 826926..827069 + 144 WP_071908341.1 DUF3265 domain-containing protein -
ASZ88_RS18450 827144..827557 + 414 WP_000049417.1 VOC family protein -
ASZ88_RS18455 827771..828022 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
ASZ88_RS18460 828012..828299 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
ASZ88_RS18465 828427..828882 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
ASZ88_RS18475 829204..829356 + 153 WP_001884520.1 DUF645 family protein -
ASZ88_RS18480 829558..830055 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
ASZ88_RS18485 830052..830324 - 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
ASZ88_RS18490 830555..831223 + 669 WP_000043871.1 hypothetical protein -
ASZ88_RS18495 831375..831662 + 288 WP_000426470.1 hypothetical protein -
ASZ88_RS18500 831803..832174 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
ASZ88_RS18505 832241..832666 + 426 WP_001882332.1 DUF1778 domain-containing protein -
ASZ88_RS18510 832663..833196 + 534 WP_000118351.1 GNAT family N-acetyltransferase -
ASZ88_RS18515 833398..833655 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
ASZ88_RS18520 833643..833945 + 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin -
ASZ88_RS18525 834179..835096 + 918 WP_000186333.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 688711..843534 154823
- inside Integron catB9 - 693791..843158 149367
flank IS/Tn - - 824372..825352 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T58341 WP_000982260.1 NZ_CP013312:c830055-829558 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T58341 NZ_CP013312:c830055-829558 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT58341 WP_000246253.1 NZ_CP013312:c830324-830052 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT58341 NZ_CP013312:c830324-830052 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References