Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-YafN |
Location | 827771..828299 | Replicon | chromosome |
Accession | NZ_CP013312 | ||
Organism | Vibrio cholerae strain E1320 |
Toxin (Protein)
Gene name | relE | Uniprot ID | A0A0X1KZS6 |
Locus tag | ASZ88_RS18460 | Protein ID | WP_000221354.1 |
Coordinates | 828012..828299 (+) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | A0A0X1KZS8 |
Locus tag | ASZ88_RS18455 | Protein ID | WP_001250179.1 |
Coordinates | 827771..828022 (+) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ASZ88_RS18405 | 823039..823353 | + | 315 | WP_000071008.1 | DNA-binding transcriptional regulator | - |
ASZ88_RS18410 | 823490..823924 | + | 435 | WP_000256036.1 | GNAT family N-acetyltransferase | - |
ASZ88_RS20985 | 824092..824247 | + | 156 | WP_000751734.1 | hypothetical protein | - |
ASZ88_RS18425 | 824372..825352 | - | 981 | WP_000019370.1 | IS5-like element ISVch5 family transposase | - |
ASZ88_RS18430 | 825420..825726 | + | 307 | Protein_835 | CatB-related O-acetyltransferase | - |
ASZ88_RS18435 | 825863..826555 | + | 693 | WP_001047169.1 | GNAT family N-acetyltransferase | - |
ASZ88_RS18440 | 826555..826956 | + | 402 | WP_000351248.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
ASZ88_RS20885 | 826926..827069 | + | 144 | WP_071908341.1 | DUF3265 domain-containing protein | - |
ASZ88_RS18450 | 827144..827557 | + | 414 | WP_000049417.1 | VOC family protein | - |
ASZ88_RS18455 | 827771..828022 | + | 252 | WP_001250179.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
ASZ88_RS18460 | 828012..828299 | + | 288 | WP_000221354.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
ASZ88_RS18465 | 828427..828882 | + | 456 | WP_001245327.1 | GNAT family N-acetyltransferase | - |
ASZ88_RS18475 | 829204..829356 | + | 153 | WP_001884520.1 | DUF645 family protein | - |
ASZ88_RS18480 | 829558..830055 | - | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
ASZ88_RS18485 | 830052..830324 | - | 273 | WP_000246253.1 | DUF1778 domain-containing protein | - |
ASZ88_RS18490 | 830555..831223 | + | 669 | WP_000043871.1 | hypothetical protein | - |
ASZ88_RS18495 | 831375..831662 | + | 288 | WP_000426470.1 | hypothetical protein | - |
ASZ88_RS18500 | 831803..832174 | + | 372 | WP_001164080.1 | nucleotide pyrophosphohydrolase | - |
ASZ88_RS18505 | 832241..832666 | + | 426 | WP_001882332.1 | DUF1778 domain-containing protein | - |
ASZ88_RS18510 | 832663..833196 | + | 534 | WP_000118351.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | catB9 | - | 688711..843534 | 154823 | |
- | inside | Integron | catB9 | - | 693791..843158 | 149367 | |
flank | IS/Tn | - | - | 824372..825352 | 980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10991.96 Da Isoelectric Point: 10.4934
>T58340 WP_000221354.1 NZ_CP013312:828012-828299 [Vibrio cholerae]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG
Download Length: 288 bp
>T58340 NZ_CP013312:828012-828299 [Vibrio cholerae]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9136.29 Da Isoelectric Point: 4.0197
>AT58340 WP_001250179.1 NZ_CP013312:827771-828022 [Vibrio cholerae]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL
Download Length: 252 bp
>AT58340 NZ_CP013312:827771-828022 [Vibrio cholerae]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0X1KZS6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0X1KZS8 |