58339

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-GNAT
Location 825863..826956 Replicon chromosome
Accession NZ_CP013312
Organism Vibrio cholerae strain E1320

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag ASZ88_RS18440 Protein ID WP_000351248.1
Coordinates 826555..826956 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag ASZ88_RS18435 Protein ID WP_001047169.1
Coordinates 825863..826555 (+) Length 231 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ88_RS18365 821146..821523 + 378 WP_000411109.1 hypothetical protein -
ASZ88_RS21210 821580..821694 + 115 Protein_826 acetyltransferase -
ASZ88_RS18370 821643..821924 + 282 WP_001894453.1 DUF1289 domain-containing protein -
ASZ88_RS18385 822090..822203 + 114 WP_001889158.1 hypothetical protein -
ASZ88_RS18390 822152..822379 + 228 WP_001894457.1 DUF1289 domain-containing protein -
ASZ88_RS18400 822720..823052 + 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin -
ASZ88_RS18405 823039..823353 + 315 WP_000071008.1 DNA-binding transcriptional regulator -
ASZ88_RS18410 823490..823924 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
ASZ88_RS20985 824092..824247 + 156 WP_000751734.1 hypothetical protein -
ASZ88_RS18425 824372..825352 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
ASZ88_RS18430 825420..825726 + 307 Protein_835 CatB-related O-acetyltransferase -
ASZ88_RS18435 825863..826555 + 693 WP_001047169.1 GNAT family N-acetyltransferase Antitoxin
ASZ88_RS18440 826555..826956 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
ASZ88_RS20885 826926..827069 + 144 WP_071908341.1 DUF3265 domain-containing protein -
ASZ88_RS18450 827144..827557 + 414 WP_000049417.1 VOC family protein -
ASZ88_RS18455 827771..828022 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
ASZ88_RS18460 828012..828299 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
ASZ88_RS18465 828427..828882 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
ASZ88_RS18475 829204..829356 + 153 WP_001884520.1 DUF645 family protein -
ASZ88_RS18480 829558..830055 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
ASZ88_RS18485 830052..830324 - 273 WP_000246253.1 DUF1778 domain-containing protein -
ASZ88_RS18490 830555..831223 + 669 WP_000043871.1 hypothetical protein -
ASZ88_RS18495 831375..831662 + 288 WP_000426470.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 688711..843534 154823
- inside Integron catB9 - 693791..843158 149367
flank IS/Tn - - 824372..825352 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin

GNAT domain

(36-153)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T58339 WP_000351248.1 NZ_CP013312:826555-826956 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T58339 NZ_CP013312:826555-826956 [Vibrio cholerae]
ATGGATATCATCTGTTTTCCTTTTGAACGAGTGATCGAGATTAATGCTTTCATCCTAAAAACAGAACCAGGAATGAAAGG
AGCCGTTGATATTCCCAAGCTTCAGGGGGCATTAGGTCGAATCGATAATGCCATCGTTTATGAAGGACTGGATGATGTTT
TTGAAATCGCTGCTAAATACACTGCTTGTATAGCGGTTTCACATGCGCTACCTGATGCGAACAAACGCACAGGTTTGGCT
GTGGCACTTGAATATTTATCACTTAACGATTTTGAGCTTACGCAGGAAAACGATTTACTTGCGGATGCAGTTCGAGATCT
TGTTATCGGCATTATCAACGAAACAGATTTTGCCGACATTCTCTACGCACAATACGCAAAAGAACAAAATTCAGCTCTCT
AA

Antitoxin


Download         Length: 231 a.a.        Molecular weight: 26352.73 Da        Isoelectric Point: 8.5633

>AT58339 WP_001047169.1 NZ_CP013312:825863-826555 [Vibrio cholerae]
MNLEEFQESDFDLLIKWIDSDELNYLWGCPAYVFPLTYEQIHSHCSKAEVFPYLLKVKGRHAGFVELYKVTDEQYRICRV
FISNAYRGQGLSKSMLMLLIDKARLDFSATKLSLGVFEQNTVARKCYESLGFEVVMVVVIEFGGMRCQPLRRALCFLSRF
GAIIGLTFIDSRCDMNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 693 bp

>AT58339 NZ_CP013312:825863-826555 [Vibrio cholerae]
ATGAACTTAGAAGAGTTTCAAGAATCGGATTTTGACCTGCTTATAAAATGGATTGACTCAGATGAGTTGAACTATTTATG
GGGTTGCCCTGCGTATGTTTTCCCGCTGACTTATGAACAGATCCATTCCCACTGTAGCAAAGCGGAAGTATTTCCCTATC
TGCTAAAAGTGAAAGGTAGACATGCCGGGTTTGTTGAGTTGTACAAAGTCACCGATGAGCAATATCGGATTTGCCGTGTC
TTTATTTCAAATGCTTATCGTGGGCAAGGGCTATCAAAATCGATGTTGATGTTATTAATCGATAAAGCCCGATTAGATTT
TTCTGCAACCAAGCTTAGCTTAGGCGTTTTTGAACAGAACACAGTTGCTAGAAAATGCTATGAGTCATTAGGTTTTGAAG
TGGTTATGGTTGTTGTGATTGAGTTTGGCGGTATGCGTTGTCAGCCCCTTAGGCGGGCGTTATGTTTTTTATCACGTTTT
GGGGCTATAATCGGCCTAACCTTTATTGATAGTAGGTGTGATATGAATCGAAAAGTTGAAGCTTACGGCGTTGATGCTGT
TGAAAGACCGAAAATTAAGGCTAGTAAAAAGCTTGATTTGACTGGTGATGCTGGTCGTCAAATTGTGAAGTCTGAAACTA
AACTTGCTTTGCGTACTCATCAGAAGACATTCACTAAATTGGCTGATATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0PN34

Antitoxin

Source ID Structure

References