Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 806443..806971 Replicon chromosome
Accession NZ_CP013312
Organism Vibrio cholerae strain E1320

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag ASZ88_RS18230 Protein ID WP_000221352.1
Coordinates 806443..806733 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag ASZ88_RS18235 Protein ID WP_000213183.1
Coordinates 806723..806971 (-) Length 83 a.a.

Genomic Context

ASZ88_RS21190ASZ88_RS21195ASZ88_RS18200ASZ88_RS18205ASZ88_RS18210ASZ88_RS20850ASZ88_RS18220ASZ88_RS18225ASZ88_RS18245ASZ88_RS18250ASZ88_RS18255ASZ88_RS18260ASZ88_RS18265ASZ88_RS18270ASZ88_RS18230ASZ88_RS18235
Location: 802000..802125 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 802141..802179 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 802392..803396 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 803549..803995 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 804115..805044 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 805041..805151 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 805179..805655 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 805792..806307 (516 bp)
Type: Others
Protein ID: WP_001201532.1
Location: 807542..808195 (654 bp)
Type: Others
Protein ID: WP_000036957.1
Location: 808467..808892 (426 bp)
Type: Others
Protein ID: WP_000415748.1
Location: 809100..809495 (396 bp)
Type: Others
Protein ID: WP_000649527.1
Location: 809646..810176 (531 bp)
Type: Others
Protein ID: WP_000415563.1
Location: 810314..810814 (501 bp)
Type: Others
Protein ID: WP_000789723.1
Location: 810970..811368 (399 bp)
Type: Others
Protein ID: WP_001882293.1
Location: 806443..806733 (291 bp)
Type: Toxin
Protein ID: WP_000221352.1
Location: 806723..806971 (249 bp)
Type: Antitoxin
Protein ID: WP_000213183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ88_RS21190802000..802125+126WP_001944767.1DUF645 family protein-
ASZ88_RS21195802141..802179+39WP_106019119.1hypothetical protein-
ASZ88_RS18200802392..803396+1005WP_000964925.1LD-carboxypeptidase-
ASZ88_RS18205803549..803995+447WP_000128977.1hypothetical protein-
ASZ88_RS18210804115..805044+930WP_000335802.1hypothetical protein-
ASZ88_RS20850805041..805151+111WP_071917832.1DUF3265 domain-containing protein-
ASZ88_RS18220805179..805655+477WP_001047180.1GNAT family N-acetyltransferase-
ASZ88_RS18225805792..806307+516WP_001201532.1lipocalin family protein-
ASZ88_RS18230806443..806733-291WP_000221352.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ASZ88_RS18235806723..806971-249WP_000213183.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
ASZ88_RS18245807542..808195+654WP_000036957.1site-specific DNA-methyltransferase-
ASZ88_RS18250808467..808892+426WP_000415748.1hypothetical protein-
ASZ88_RS18255809100..809495+396WP_000649527.1DUF3465 domain-containing protein-
ASZ88_RS18260809646..810176+531WP_000415563.1hypothetical protein-
ASZ88_RS18265810314..810814+501WP_000789723.1hypothetical protein-
ASZ88_RS18270810970..811368+399WP_001882293.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-688711..843534154823
-insideIntegroncatB9-693791..843158149367
flankIS/Tn--811607..812044437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T58337 WP_000221352.1 NZ_CP013312:c806733-806443 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T58337 NZ_CP013312:c806733-806443 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT58337 WP_000213183.1 NZ_CP013312:c806971-806723 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT58337 NZ_CP013312:c806971-806723 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBH9L4R3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366A3W8

References