58337

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 806443..806971 Replicon chromosome
Accession NZ_CP013312
Organism Vibrio cholerae strain E1320

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag ASZ88_RS18230 Protein ID WP_000221352.1
Coordinates 806443..806733 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag ASZ88_RS18235 Protein ID WP_000213183.1
Coordinates 806723..806971 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ88_RS21190 802000..802125 + 126 WP_001944767.1 DUF645 family protein -
ASZ88_RS21195 802141..802179 + 39 WP_106019119.1 hypothetical protein -
ASZ88_RS18200 802392..803396 + 1005 WP_000964925.1 LD-carboxypeptidase -
ASZ88_RS18205 803549..803995 + 447 WP_000128977.1 hypothetical protein -
ASZ88_RS18210 804115..805044 + 930 WP_000335802.1 hypothetical protein -
ASZ88_RS20850 805041..805151 + 111 WP_071917832.1 DUF3265 domain-containing protein -
ASZ88_RS18220 805179..805655 + 477 WP_001047180.1 GNAT family N-acetyltransferase -
ASZ88_RS18225 805792..806307 + 516 WP_001201532.1 lipocalin family protein -
ASZ88_RS18230 806443..806733 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ASZ88_RS18235 806723..806971 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ASZ88_RS18245 807542..808195 + 654 WP_000036957.1 site-specific DNA-methyltransferase -
ASZ88_RS18250 808467..808892 + 426 WP_000415748.1 hypothetical protein -
ASZ88_RS18255 809100..809495 + 396 WP_000649527.1 DUF3465 domain-containing protein -
ASZ88_RS18260 809646..810176 + 531 WP_000415563.1 hypothetical protein -
ASZ88_RS18265 810314..810814 + 501 WP_000789723.1 hypothetical protein -
ASZ88_RS18270 810970..811368 + 399 WP_001882293.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 688711..843534 154823
- inside Integron catB9 - 693791..843158 149367
flank IS/Tn - - 811607..812044 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T58337 WP_000221352.1 NZ_CP013312:c806733-806443 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T58337 NZ_CP013312:c806733-806443 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT58337 WP_000213183.1 NZ_CP013312:c806971-806723 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT58337 NZ_CP013312:c806971-806723 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References