Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 440451..441217 Replicon chromosome
Accession NZ_CP013308
Organism Vibrio cholerae strain E506

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag ASZ84_RS16720 Protein ID WP_000982260.1
Coordinates 440451..440948 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag ASZ84_RS16725 Protein ID WP_000246253.1
Coordinates 440945..441217 (-) Length 91 a.a.

Genomic Context

ASZ84_RS16675ASZ84_RS16680ASZ84_RS16685ASZ84_RS20150ASZ84_RS16690ASZ84_RS16695ASZ84_RS16700ASZ84_RS16705ASZ84_RS16715ASZ84_RS16735ASZ84_RS16740ASZ84_RS16745ASZ84_RS16750ASZ84_RS16755ASZ84_RS16760ASZ84_RS16765ASZ84_RS16775ASZ84_RS16720ASZ84_RS16725
Location: 436313..436619 (307 bp)
Type: Others
Protein ID: Protein_465
Location: 436756..437448 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 437448..437849 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 437819..437962 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 438037..438450 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 438664..438915 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 438905..439192 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 439320..439775 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 440097..440249 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 441448..442116 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 442268..442555 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 442696..443067 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 443134..443559 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 443556..444089 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 444291..444548 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 444536..444838 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 445109..445993 (885 bp)
Type: Others
Protein ID: WP_000842472.1
Location: 440451..440948 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 440945..441217 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ84_RS16675436313..436619+307Protein_465CatB-related O-acetyltransferase-
ASZ84_RS16680436756..437448+693WP_001047169.1GNAT family N-acetyltransferase-
ASZ84_RS16685437448..437849+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
ASZ84_RS20150437819..437962+144WP_071908341.1DUF3265 domain-containing protein-
ASZ84_RS16690438037..438450+414WP_000049417.1VOC family protein-
ASZ84_RS16695438664..438915+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ84_RS16700438905..439192+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ84_RS16705439320..439775+456WP_001245327.1GNAT family N-acetyltransferase-
ASZ84_RS16715440097..440249+153WP_001884520.1DUF645 family protein-
ASZ84_RS16720440451..440948-498WP_000982260.1GNAT family N-acetyltransferaseToxin
ASZ84_RS16725440945..441217-273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
ASZ84_RS16735441448..442116+669WP_000043871.1hypothetical protein-
ASZ84_RS16740442268..442555+288WP_000426470.1hypothetical protein-
ASZ84_RS16745442696..443067+372WP_001164080.1nucleotide pyrophosphohydrolase-
ASZ84_RS16750443134..443559+426WP_001882332.1DUF1778 domain-containing protein-
ASZ84_RS16755443556..444089+534WP_000118351.1GNAT family N-acetyltransferase-
ASZ84_RS16760444291..444548+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ84_RS16765444536..444838+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ84_RS16775445109..445993+885WP_000842472.1DUF3800 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--304088..451655147567
-insideIntegron--309168..451279142111
flankIS/Tn--435265..436245980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T58294 WP_000982260.1 NZ_CP013308:c440948-440451 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T58294 NZ_CP013308:c440948-440451 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT58294 WP_000246253.1 NZ_CP013308:c441217-440945 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT58294 NZ_CP013308:c441217-440945 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References