58292

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-GNAT
Location 436756..437849 Replicon chromosome
Accession NZ_CP013308
Organism Vibrio cholerae strain E506

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag ASZ84_RS16685 Protein ID WP_000351248.1
Coordinates 437448..437849 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag ASZ84_RS16680 Protein ID WP_001047169.1
Coordinates 436756..437448 (+) Length 231 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ84_RS16610 432039..432416 + 378 WP_000411109.1 hypothetical protein -
ASZ84_RS20480 432473..432587 + 115 Protein_456 acetyltransferase -
ASZ84_RS16615 432536..432817 + 282 WP_001894453.1 DUF1289 domain-containing protein -
ASZ84_RS16630 432983..433096 + 114 WP_001889158.1 hypothetical protein -
ASZ84_RS16635 433045..433272 + 228 WP_001894457.1 DUF1289 domain-containing protein -
ASZ84_RS16645 433613..433945 + 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin -
ASZ84_RS16650 433932..434246 + 315 WP_000071008.1 DNA-binding transcriptional regulator -
ASZ84_RS16655 434383..434817 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
ASZ84_RS20250 434985..435140 + 156 WP_000751734.1 hypothetical protein -
ASZ84_RS16670 435265..436245 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
ASZ84_RS16675 436313..436619 + 307 Protein_465 CatB-related O-acetyltransferase -
ASZ84_RS16680 436756..437448 + 693 WP_001047169.1 GNAT family N-acetyltransferase Antitoxin
ASZ84_RS16685 437448..437849 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
ASZ84_RS20150 437819..437962 + 144 WP_071908341.1 DUF3265 domain-containing protein -
ASZ84_RS16690 438037..438450 + 414 WP_000049417.1 VOC family protein -
ASZ84_RS16695 438664..438915 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
ASZ84_RS16700 438905..439192 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
ASZ84_RS16705 439320..439775 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
ASZ84_RS16715 440097..440249 + 153 WP_001884520.1 DUF645 family protein -
ASZ84_RS16720 440451..440948 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
ASZ84_RS16725 440945..441217 - 273 WP_000246253.1 DUF1778 domain-containing protein -
ASZ84_RS16735 441448..442116 + 669 WP_000043871.1 hypothetical protein -
ASZ84_RS16740 442268..442555 + 288 WP_000426470.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 304088..451655 147567
- inside Integron - - 309168..451279 142111
flank IS/Tn - - 435265..436245 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin

GNAT domain

(36-153)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T58292 WP_000351248.1 NZ_CP013308:437448-437849 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T58292 NZ_CP013308:437448-437849 [Vibrio cholerae]
ATGGATATCATCTGTTTTCCTTTTGAACGAGTGATCGAGATTAATGCTTTCATCCTAAAAACAGAACCAGGAATGAAAGG
AGCCGTTGATATTCCCAAGCTTCAGGGGGCATTAGGTCGAATCGATAATGCCATCGTTTATGAAGGACTGGATGATGTTT
TTGAAATCGCTGCTAAATACACTGCTTGTATAGCGGTTTCACATGCGCTACCTGATGCGAACAAACGCACAGGTTTGGCT
GTGGCACTTGAATATTTATCACTTAACGATTTTGAGCTTACGCAGGAAAACGATTTACTTGCGGATGCAGTTCGAGATCT
TGTTATCGGCATTATCAACGAAACAGATTTTGCCGACATTCTCTACGCACAATACGCAAAAGAACAAAATTCAGCTCTCT
AA

Antitoxin


Download         Length: 231 a.a.        Molecular weight: 26352.73 Da        Isoelectric Point: 8.5633

>AT58292 WP_001047169.1 NZ_CP013308:436756-437448 [Vibrio cholerae]
MNLEEFQESDFDLLIKWIDSDELNYLWGCPAYVFPLTYEQIHSHCSKAEVFPYLLKVKGRHAGFVELYKVTDEQYRICRV
FISNAYRGQGLSKSMLMLLIDKARLDFSATKLSLGVFEQNTVARKCYESLGFEVVMVVVIEFGGMRCQPLRRALCFLSRF
GAIIGLTFIDSRCDMNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 693 bp

>AT58292 NZ_CP013308:436756-437448 [Vibrio cholerae]
ATGAACTTAGAAGAGTTTCAAGAATCGGATTTTGACCTGCTTATAAAATGGATTGACTCAGATGAGTTGAACTATTTATG
GGGTTGCCCTGCGTATGTTTTCCCGCTGACTTATGAACAGATCCATTCCCACTGTAGCAAAGCGGAAGTATTTCCCTATC
TGCTAAAAGTGAAAGGTAGACATGCCGGGTTTGTTGAGTTGTACAAAGTCACCGATGAGCAATATCGGATTTGCCGTGTC
TTTATTTCAAATGCTTATCGTGGGCAAGGGCTATCAAAATCGATGTTGATGTTATTAATCGATAAAGCCCGATTAGATTT
TTCTGCAACCAAGCTTAGCTTAGGCGTTTTTGAACAGAACACAGTTGCTAGAAAATGCTATGAGTCATTAGGTTTTGAAG
TGGTTATGGTTGTTGTGATTGAGTTTGGCGGTATGCGTTGTCAGCCCCTTAGGCGGGCGTTATGTTTTTTATCACGTTTT
GGGGCTATAATCGGCCTAACCTTTATTGATAGTAGGTGTGATATGAATCGAAAAGTTGAAGCTTACGGCGTTGATGCTGT
TGAAAGACCGAAAATTAAGGCTAGTAAAAAGCTTGATTTGACTGGTGATGCTGGTCGTCAAATTGTGAAGTCTGAAACTA
AACTTGCTTTGCGTACTCATCAGAAGACATTCACTAAATTGGCTGATATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0PN34

Antitoxin

Source ID Structure

References