Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 848144..848672 Replicon chromosome
Accession NZ_CP013013
Organism Vibrio cholerae strain Env-390

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag AP033_RS03865 Protein ID WP_000221354.1
Coordinates 848144..848431 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag AP033_RS03870 Protein ID WP_001250179.1
Coordinates 848421..848672 (-) Length 84 a.a.

Genomic Context

AP033_RS03845AP033_RS03850AP033_RS03895AP033_RS03825AP033_RS03830AP033_RS03835AP033_RS03840AP033_RS03855AP033_RS03860AP033_RS03865AP033_RS03870AP033_RS03875AP033_RS19795AP033_RS03880AP033_RS03885AP033_RS03890AP033_RS03900AP033_RS19800
Location: 846118..846390 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 846387..846884 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 851091..852071 (981 bp)
Type: Others
Protein ID: WP_000019368.1
Location: 843491..843793 (303 bp)
Type: Others
Protein ID: WP_000229325.1
Location: 843781..844038 (258 bp)
Type: Others
Protein ID: WP_070961997.1
Location: 844511..845491 (981 bp)
Type: Others
Protein ID: WP_000019368.1
Location: 845561..845887 (327 bp)
Type: Others
Protein ID: Protein_748
Location: 847087..847239 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 847561..848016 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 848144..848431 (288 bp)
Type: Toxin
Protein ID: WP_000221354.1
Location: 848421..848672 (252 bp)
Type: Antitoxin
Protein ID: WP_001250179.1
Location: 848886..849299 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 849374..849517 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 849487..849888 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 849888..850580 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 850751..851023 (273 bp)
Type: Others
Protein ID: Protein_759
Location: 852196..852396 (201 bp)
Type: Others
Protein ID: WP_001198130.1
Location: 852756..852929 (174 bp)
Type: Others
Protein ID: WP_001882305.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AP033_RS03825843491..843793-303WP_000229325.1type II toxin-antitoxin system RelE/ParE family toxin-
AP033_RS03830843781..844038-258WP_070961997.1type II toxin-antitoxin system Phd/YefM family antitoxin-
AP033_RS03835844511..845491-981WP_000019368.1IS5-like element ISVch5 family transposase-
AP033_RS03840845561..845887-327Protein_748hypothetical protein-
AP033_RS03845846118..846390+273WP_000246253.1DUF1778 domain-containing protein-
AP033_RS03850846387..846884+498WP_000982260.1GNAT family N-acetyltransferase-
AP033_RS03855847087..847239-153WP_001884520.1DUF645 family protein-
AP033_RS03860847561..848016-456WP_001245327.1GNAT family N-acetyltransferase-
AP033_RS03865848144..848431-288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxinToxin
AP033_RS03870848421..848672-252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
AP033_RS03875848886..849299-414WP_000049417.1VOC family protein-
AP033_RS19795849374..849517-144WP_071908341.1DUF3265 domain-containing protein-
AP033_RS03880849487..849888-402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
AP033_RS03885849888..850580-693WP_001047169.1GNAT family N-acetyltransferase-
AP033_RS03890850751..851023-273Protein_759CatB-related O-acetyltransferase-
AP033_RS03895851091..852071+981WP_000019368.1IS5-like element ISVch5 family transposase-
AP033_RS03900852196..852396-201WP_001198130.1hypothetical protein-
AP033_RS19800852756..852929-174WP_001882305.1DUF3709 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
flankIS/Tn--844511..845491980
flankIS/Tn--851091..852071980
-insideIntegron--829699..942463112764


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T57707 WP_000221354.1 NZ_CP013013:c848431-848144 [Vibrio cholerae]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T57707 NZ_CP013013:c848431-848144 [Vibrio cholerae]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT57707 WP_001250179.1 NZ_CP013013:c848672-848421 [Vibrio cholerae]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT57707 NZ_CP013013:c848672-848421 [Vibrio cholerae]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0X1KZS6

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0X1KZS8

References