57706

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 846118..846884 Replicon chromosome
Accession NZ_CP013013
Organism Vibrio cholerae strain Env-390

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag AP033_RS03850 Protein ID WP_000982260.1
Coordinates 846387..846884 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag AP033_RS03845 Protein ID WP_000246253.1
Coordinates 846118..846390 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AP033_RS03815 841151..841522 - 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
AP033_RS03820 841770..842030 - 261 WP_032468027.1 DUF3709 domain-containing protein -
AP033_RS19075 842048..842208 - 161 Protein_742 DUF3709 domain-containing protein -
AP033_RS19080 842442..842666 - 225 WP_161571222.1 DUF3709 domain-containing protein -
AP033_RS19085 842996..843106 - 111 WP_076025930.1 DUF645 family protein -
AP033_RS03825 843491..843793 - 303 WP_000229325.1 type II toxin-antitoxin system RelE/ParE family toxin -
AP033_RS03830 843781..844038 - 258 WP_070961997.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
AP033_RS03835 844511..845491 - 981 WP_000019368.1 IS5-like element ISVch5 family transposase -
AP033_RS03840 845561..845887 - 327 Protein_748 hypothetical protein -
AP033_RS03845 846118..846390 + 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
AP033_RS03850 846387..846884 + 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
AP033_RS03855 847087..847239 - 153 WP_001884520.1 DUF645 family protein -
AP033_RS03860 847561..848016 - 456 WP_001245327.1 GNAT family N-acetyltransferase -
AP033_RS03865 848144..848431 - 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
AP033_RS03870 848421..848672 - 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
AP033_RS03875 848886..849299 - 414 WP_000049417.1 VOC family protein -
AP033_RS19795 849374..849517 - 144 WP_071908341.1 DUF3265 domain-containing protein -
AP033_RS03880 849487..849888 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
AP033_RS03885 849888..850580 - 693 WP_001047169.1 GNAT family N-acetyltransferase -
AP033_RS03890 850751..851023 - 273 Protein_759 CatB-related O-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 844511..845491 980
flank IS/Tn - - 851091..852071 980
- inside Integron - - 829699..942463 112764


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T57706 WP_000982260.1 NZ_CP013013:846387-846884 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T57706 NZ_CP013013:846387-846884 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT57706 WP_000246253.1 NZ_CP013013:846118-846390 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT57706 NZ_CP013013:846118-846390 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References