Detailed information of TA system TA057705

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-Phd
• Location: 843491..844038
• Replicon: chromosome
• Accession: NZ_CP013013
• Organism: Vibrio cholerae strain Env-390

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: AP033_RS03825
• Protein ID: WP_000229325.1
• Coordinates: 843491..843793 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: AP033_RS03830
• Protein ID: WP_070961997.1
• Coordinates: 843781..844038 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AP033_RS03795	839380..839682	-	303	WP_000229317.1	type II toxin-antitoxin system RelE/ParE family toxin	-
AP033_RS03800	839670..839927	-	258	WP_000861987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
AP033_RS03805	840129..840662	-	534	WP_000118351.1	GNAT family N-acetyltransferase	-
AP033_RS20035	840659..841084	-	426	WP_001882332.1	DUF1778 domain-containing protein	-
AP033_RS03815	841151..841522	-	372	WP_001164080.1	nucleotide pyrophosphohydrolase	-
AP033_RS03820	841770..842030	-	261	WP_032468027.1	DUF3709 domain-containing protein	-
AP033_RS19075	842048..842208	-	161	Protein_742	DUF3709 domain-containing protein	-
AP033_RS19080	842442..842666	-	225	WP_161571222.1	DUF3709 domain-containing protein	-
AP033_RS19085	842996..843106	-	111	WP_076025930.1	DUF645 family protein	-
AP033_RS03825	843491..843793	-	303	WP_000229325.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AP033_RS03830	843781..844038	-	258	WP_070961997.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
AP033_RS03835	844511..845491	-	981	WP_000019368.1	IS5-like element ISVch5 family transposase	-
AP033_RS03840	845561..845887	-	327	Protein_748	hypothetical protein	-
AP033_RS03845	846118..846390	+	273	WP_000246253.1	DUF1778 domain-containing protein	-
AP033_RS03850	846387..846884	+	498	WP_000982260.1	GNAT family N-acetyltransferase	-
AP033_RS03855	847087..847239	-	153	WP_001884520.1	DUF645 family protein	-
AP033_RS03860	847561..848016	-	456	WP_001245327.1	GNAT family N-acetyltransferase	-
AP033_RS03865	848144..848431	-	288	WP_000221354.1	type II toxin-antitoxin system RelE/ParE family toxin	-
AP033_RS03870	848421..848672	-	252	WP_001250179.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 IS/Tn TA000174, TA000175, TA000176, TA010030 416601..417581 0.001	flank	IS/Tn	-	-	844511..845491	980
	-	inside	Integron	-	-	829699..942463	112764

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11710.64 Da
• Isoelectric Point: 5.1972

>T57705 WP_000229325.1 NZ_CP013013:c843793-843491 [Vibrio cholerae]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Nucleotide

• Length: 303 bp

>T57705 NZ_CP013013:c843793-843491 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCCGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCTCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9629.12 Da
• Isoelectric Point: 7.3178

>AT57705 WP_070961997.1 NZ_CP013013:c844038-843781 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRI
SKWLK

Nucleotide

• Length: 258 bp

>AT57705 NZ_CP013013:c844038-843781 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCTTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATA
TCAAAATGGTTGAAATAA