Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) dhiT-phd/-
Location 833775..834179 Replicon chromosome
Accession NZ_CP013013
Organism Vibrio cholerae strain Env-390

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag AP033_RS03750 Protein ID WP_001114075.1
Coordinates 833775..834044 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag AP033_RS19775 Protein ID WP_099607150.1
Coordinates 834075..834179 (-) Length 35 a.a.

Genomic Context

AP033_RS03730AP033_RS03735AP033_RS03720AP033_RS03725AP033_RS03740AP033_RS19770AP033_RS03745AP033_RS03750AP033_RS19775AP033_RS03755AP033_RS03760AP033_RS03765AP033_RS03770AP033_RS03775AP033_RS03780AP033_RS03785AP033_RS03790
Location: 831492..831776 (285 bp)
Type: Others
Protein ID: WP_000381183.1
Location: 831773..832051 (279 bp)
Type: Others
Protein ID: WP_000578476.1
Location: 830186..830599 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 830783..831298 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 832190..832585 (396 bp)
Type: Others
Protein ID: WP_001000868.1
Location: 832836..832961 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 833260..833781 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 833775..834044 (270 bp)
Type: Toxin
Protein ID: WP_001114075.1
Location: 834075..834179 (105 bp)
Type: Antitoxin
Protein ID: WP_099607150.1
Location: 834236..834835 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 834985..835857 (873 bp)
Type: Others
Protein ID: WP_000254717.1
Location: 836032..836250 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 836314..836751 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 836870..837079 (210 bp)
Type: Others
Protein ID: Protein_732
Location: 837215..837604 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 837779..838021 (243 bp)
Type: Others
Protein ID: WP_000107462.1
Location: 838229..839146 (918 bp)
Type: Others
Protein ID: WP_033935911.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AP033_RS03720830186..830599-414WP_000049420.1VOC family protein-
AP033_RS03725830783..831298-516WP_000343779.1GNAT family N-acetyltransferase-
AP033_RS03730831492..831776+285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
AP033_RS03735831773..832051+279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family-
AP033_RS03740832190..832585-396WP_001000868.1hypothetical protein-
AP033_RS19770832836..832961-126WP_001905700.1DUF645 family protein-
AP033_RS03745833260..833781-522WP_000921691.1DUF2442 domain-containing protein-
AP033_RS03750833775..834044-270WP_001114075.1DUF4160 domain-containing proteinToxin
AP033_RS19775834075..834179-105WP_099607150.1acetyltransferaseAntitoxin
AP033_RS03755834236..834835-600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
AP033_RS03760834985..835857-873WP_000254717.1DUF3800 domain-containing protein-
AP033_RS03765836032..836250-219WP_071908318.1GNAT family N-acetyltransferase-
AP033_RS03770836314..836751-438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
AP033_RS03775836870..837079-210Protein_732GNAT family N-acetyltransferase-
AP033_RS03780837215..837604-390WP_001081302.1hypothetical protein-
AP033_RS03785837779..838021-243WP_000107462.1hypothetical protein-
AP033_RS03790838229..839146-918WP_033935911.1alpha/beta hydrolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
flankIS/Tn--836314..836751437
-insideIntegron--829699..942463112764


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T57702 WP_001114075.1 NZ_CP013013:c834044-833775 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T57702 NZ_CP013013:c834044-833775 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 35 a.a.        Molecular weight: 3991.79 Da        Isoelectric Point: 9.2853

>AT57702 WP_099607150.1 NZ_CP013013:c834179-834075 [Vibrio cholerae]
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL

Download         Length: 105 bp

>AT57702 NZ_CP013013:c834179-834075 [Vibrio cholerae]
GTGGTTTCGGTTGTTGTGTTTGAGTTTAGTAGTATGCGCTGCCAGCCCCTTAGGCGGGCGTTATATGCTTATAGGAATTG
TCTCCTAAAGGATACGCTGCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A086SLD6

Antitoxin

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Source
ID
Structure
No matching records found

References