57700

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 831492..832051 Replicon chromosome
Accession NZ_CP013013
Organism Vibrio cholerae strain Env-390

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag AP033_RS03735 Protein ID WP_000578476.1
Coordinates 831773..832051 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag AP033_RS03730 Protein ID WP_000381183.1
Coordinates 831492..831776 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AP033_RS03700 826703..827332 - 630 WP_001284008.1 DnaJ domain-containing protein -
AP033_RS03705 827568..828155 + 588 WP_001131372.1 DUF2238 domain-containing protein -
AP033_RS03720 830186..830599 - 414 WP_000049420.1 VOC family protein -
AP033_RS03725 830783..831298 - 516 WP_000343779.1 GNAT family N-acetyltransferase -
AP033_RS03730 831492..831776 + 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AP033_RS03735 831773..832051 + 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
AP033_RS03740 832190..832585 - 396 WP_001000868.1 hypothetical protein -
AP033_RS19770 832836..832961 - 126 WP_001905700.1 DUF645 family protein -
AP033_RS03745 833260..833781 - 522 WP_000921691.1 DUF2442 domain-containing protein -
AP033_RS03750 833775..834044 - 270 WP_001114075.1 DUF4160 domain-containing protein -
AP033_RS19775 834075..834179 - 105 WP_099607150.1 acetyltransferase -
AP033_RS03755 834236..834835 - 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
AP033_RS03760 834985..835857 - 873 WP_000254717.1 DUF3800 domain-containing protein -
AP033_RS03765 836032..836250 - 219 WP_071908318.1 GNAT family N-acetyltransferase -
AP033_RS03770 836314..836751 - 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 836314..836751 437
- inside Integron - - 829699..942463 112764


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T57700 WP_000578476.1 NZ_CP013013:831773-832051 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T57700 NZ_CP013013:831773-832051 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT57700 WP_000381183.1 NZ_CP013013:831492-831776 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT57700 NZ_CP013013:831492-831776 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References