57660

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 846946..847474 Replicon chromosome
Accession NZ_CP012997
Organism Vibrio cholerae strain 2012Env-9

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag NH62_RS03855 Protein ID WP_000221354.1
Coordinates 846946..847233 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag NH62_RS03860 Protein ID WP_001250179.1
Coordinates 847223..847474 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NH62_RS03815 842293..842595 - 303 WP_000229325.1 type II toxin-antitoxin system RelE/ParE family toxin -
NH62_RS03820 842583..842840 - 258 WP_070961997.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
NH62_RS03825 843313..844293 - 981 WP_000019368.1 IS5-like element ISVch5 family transposase -
NH62_RS03830 844363..844689 - 327 Protein_746 hypothetical protein -
NH62_RS03835 844920..845192 + 273 WP_000246253.1 DUF1778 domain-containing protein -
NH62_RS03840 845189..845686 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
NH62_RS03845 845889..846041 - 153 WP_001884520.1 DUF645 family protein -
NH62_RS03850 846363..846818 - 456 WP_001245327.1 GNAT family N-acetyltransferase -
NH62_RS03855 846946..847233 - 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NH62_RS03860 847223..847474 - 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NH62_RS03865 847688..848101 - 414 WP_000049417.1 VOC family protein -
NH62_RS19860 848176..848319 - 144 WP_071908341.1 DUF3265 domain-containing protein -
NH62_RS03870 848289..848690 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
NH62_RS03875 848690..849382 - 693 WP_001047169.1 GNAT family N-acetyltransferase -
NH62_RS03880 849519..849825 - 307 Protein_757 CatB-related O-acetyltransferase -
NH62_RS03885 849893..850873 + 981 WP_000019368.1 IS5-like element ISVch5 family transposase -
NH62_RS03890 850998..851198 - 201 WP_001198130.1 hypothetical protein -
NH62_RS19865 851558..851731 - 174 WP_001882305.1 DUF3709 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 827256..947647 120391
flank IS/Tn - - 843313..844293 980
flank IS/Tn - - 849893..850873 980
- inside Integron - - 828501..941266 112765


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T57660 WP_000221354.1 NZ_CP012997:c847233-846946 [Vibrio cholerae]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T57660 NZ_CP012997:c847233-846946 [Vibrio cholerae]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT57660 WP_001250179.1 NZ_CP012997:c847474-847223 [Vibrio cholerae]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT57660 NZ_CP012997:c847474-847223 [Vibrio cholerae]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X1KZS6

Antitoxin

Source ID Structure
AlphaFold DB A0A0X1KZS8

References