Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 844920..845686 Replicon chromosome
Accession NZ_CP012997
Organism Vibrio cholerae strain 2012Env-9

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag NH62_RS03840 Protein ID WP_000982260.1
Coordinates 845189..845686 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag NH62_RS03835 Protein ID WP_000246253.1
Coordinates 844920..845192 (+) Length 91 a.a.

Genomic Context

NH62_RS03835NH62_RS03840NH62_RS03805NH62_RS03810NH62_RS19125NH62_RS19130NH62_RS19135NH62_RS03815NH62_RS03820NH62_RS03825NH62_RS03830NH62_RS03845NH62_RS03850NH62_RS03855NH62_RS03860NH62_RS03865NH62_RS19860NH62_RS03870NH62_RS03875NH62_RS03880
Location: 844920..845192 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
Location: 845189..845686 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 839953..840324 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 840572..840832 (261 bp)
Type: Others
Protein ID: WP_032468027.1
Location: 840850..841010 (161 bp)
Type: Others
Protein ID: Protein_740
Location: 841244..841468 (225 bp)
Type: Others
Protein ID: WP_161571222.1
Location: 841798..841908 (111 bp)
Type: Others
Protein ID: WP_076025930.1
Location: 842293..842595 (303 bp)
Type: Others
Protein ID: WP_000229325.1
Location: 842583..842840 (258 bp)
Type: Others
Protein ID: WP_070961997.1
Location: 843313..844293 (981 bp)
Type: Others
Protein ID: WP_000019368.1
Location: 844363..844689 (327 bp)
Type: Others
Protein ID: Protein_746
Location: 845889..846041 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 846363..846818 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 846946..847233 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 847223..847474 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 847688..848101 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 848176..848319 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 848289..848690 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 848690..849382 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 849519..849825 (307 bp)
Type: Others
Protein ID: Protein_757
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NH62_RS03805839953..840324-372WP_001164080.1nucleotide pyrophosphohydrolase-
NH62_RS03810840572..840832-261WP_032468027.1DUF3709 domain-containing protein-
NH62_RS19125840850..841010-161Protein_740DUF3709 domain-containing protein-
NH62_RS19130841244..841468-225WP_161571222.1DUF3709 domain-containing protein-
NH62_RS19135841798..841908-111WP_076025930.1DUF645 family protein-
NH62_RS03815842293..842595-303WP_000229325.1type II toxin-antitoxin system RelE/ParE family toxin-
NH62_RS03820842583..842840-258WP_070961997.1type II toxin-antitoxin system Phd/YefM family antitoxin-
NH62_RS03825843313..844293-981WP_000019368.1IS5-like element ISVch5 family transposase-
NH62_RS03830844363..844689-327Protein_746hypothetical protein-
NH62_RS03835844920..845192+273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
NH62_RS03840845189..845686+498WP_000982260.1GNAT family N-acetyltransferaseToxin
NH62_RS03845845889..846041-153WP_001884520.1DUF645 family protein-
NH62_RS03850846363..846818-456WP_001245327.1GNAT family N-acetyltransferase-
NH62_RS03855846946..847233-288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
NH62_RS03860847223..847474-252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
NH62_RS03865847688..848101-414WP_000049417.1VOC family protein-
NH62_RS19860848176..848319-144WP_071908341.1DUF3265 domain-containing protein-
NH62_RS03870848289..848690-402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
NH62_RS03875848690..849382-693WP_001047169.1GNAT family N-acetyltransferase-
NH62_RS03880849519..849825-307Protein_757CatB-related O-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-827256..947647120391
flankIS/Tn--843313..844293980
flankIS/Tn--849893..850873980
-insideIntegron--828501..941266112765


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T57659 WP_000982260.1 NZ_CP012997:845189-845686 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T57659 NZ_CP012997:845189-845686 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT57659 WP_000246253.1 NZ_CP012997:844920-845192 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT57659 NZ_CP012997:844920-845192 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References