57659

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 844920..845686 Replicon chromosome
Accession NZ_CP012997
Organism Vibrio cholerae strain 2012Env-9

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag NH62_RS03840 Protein ID WP_000982260.1
Coordinates 845189..845686 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag NH62_RS03835 Protein ID WP_000246253.1
Coordinates 844920..845192 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NH62_RS03805 839953..840324 - 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
NH62_RS03810 840572..840832 - 261 WP_032468027.1 DUF3709 domain-containing protein -
NH62_RS19125 840850..841010 - 161 Protein_740 DUF3709 domain-containing protein -
NH62_RS19130 841244..841468 - 225 WP_161571222.1 DUF3709 domain-containing protein -
NH62_RS19135 841798..841908 - 111 WP_076025930.1 DUF645 family protein -
NH62_RS03815 842293..842595 - 303 WP_000229325.1 type II toxin-antitoxin system RelE/ParE family toxin -
NH62_RS03820 842583..842840 - 258 WP_070961997.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
NH62_RS03825 843313..844293 - 981 WP_000019368.1 IS5-like element ISVch5 family transposase -
NH62_RS03830 844363..844689 - 327 Protein_746 hypothetical protein -
NH62_RS03835 844920..845192 + 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
NH62_RS03840 845189..845686 + 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
NH62_RS03845 845889..846041 - 153 WP_001884520.1 DUF645 family protein -
NH62_RS03850 846363..846818 - 456 WP_001245327.1 GNAT family N-acetyltransferase -
NH62_RS03855 846946..847233 - 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
NH62_RS03860 847223..847474 - 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
NH62_RS03865 847688..848101 - 414 WP_000049417.1 VOC family protein -
NH62_RS19860 848176..848319 - 144 WP_071908341.1 DUF3265 domain-containing protein -
NH62_RS03870 848289..848690 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
NH62_RS03875 848690..849382 - 693 WP_001047169.1 GNAT family N-acetyltransferase -
NH62_RS03880 849519..849825 - 307 Protein_757 CatB-related O-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 827256..947647 120391
flank IS/Tn - - 843313..844293 980
flank IS/Tn - - 849893..850873 980
- inside Integron - - 828501..941266 112765


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T57659 WP_000982260.1 NZ_CP012997:845189-845686 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T57659 NZ_CP012997:845189-845686 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT57659 WP_000246253.1 NZ_CP012997:844920-845192 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT57659 NZ_CP012997:844920-845192 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References