Detailed information of TA system TA057658

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-Phd
• Location: 842293..842840
• Replicon: chromosome
• Accession: NZ_CP012997
• Organism: Vibrio cholerae strain 2012Env-9

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: NH62_RS03815
• Protein ID: WP_000229325.1
• Coordinates: 842293..842595 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: NH62_RS03820
• Protein ID: WP_070961997.1
• Coordinates: 842583..842840 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NH62_RS03785	838182..838484	-	303	WP_000229317.1	type II toxin-antitoxin system RelE/ParE family toxin	-
NH62_RS03790	838472..838729	-	258	WP_000861987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
NH62_RS03795	838931..839464	-	534	WP_000118351.1	GNAT family N-acetyltransferase	-
NH62_RS03800	839461..839886	-	426	WP_001882332.1	DUF1778 domain-containing protein	-
NH62_RS03805	839953..840324	-	372	WP_001164080.1	nucleotide pyrophosphohydrolase	-
NH62_RS03810	840572..840832	-	261	WP_032468027.1	DUF3709 domain-containing protein	-
NH62_RS19125	840850..841010	-	161	Protein_740	DUF3709 domain-containing protein	-
NH62_RS19130	841244..841468	-	225	WP_161571222.1	DUF3709 domain-containing protein	-
NH62_RS19135	841798..841908	-	111	WP_076025930.1	DUF645 family protein	-
NH62_RS03815	842293..842595	-	303	WP_000229325.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
NH62_RS03820	842583..842840	-	258	WP_070961997.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
NH62_RS03825	843313..844293	-	981	WP_000019368.1	IS5-like element ISVch5 family transposase	-
NH62_RS03830	844363..844689	-	327	Protein_746	hypothetical protein	-
NH62_RS03835	844920..845192	+	273	WP_000246253.1	DUF1778 domain-containing protein	-
NH62_RS03840	845189..845686	+	498	WP_000982260.1	GNAT family N-acetyltransferase	-
NH62_RS03845	845889..846041	-	153	WP_001884520.1	DUF645 family protein	-
NH62_RS03850	846363..846818	-	456	WP_001245327.1	GNAT family N-acetyltransferase	-
NH62_RS03855	846946..847233	-	288	WP_000221354.1	type II toxin-antitoxin system RelE/ParE family toxin	-
NH62_RS03860	847223..847474	-	252	WP_001250179.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	827256..947647	120391
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 IS/Tn TA000174, TA000175, TA000176, TA010030 416601..417581 0.001	flank	IS/Tn	-	-	843313..844293	980
	-	inside	Integron	-	-	828501..941266	112765

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11710.64 Da
• Isoelectric Point: 5.1972

>T57658 WP_000229325.1 NZ_CP012997:c842595-842293 [Vibrio cholerae]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Nucleotide

• Length: 303 bp

>T57658 NZ_CP012997:c842595-842293 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCCGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCTCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9629.12 Da
• Isoelectric Point: 7.3178

>AT57658 WP_070961997.1 NZ_CP012997:c842840-842583 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRI
SKWLK

Nucleotide

• Length: 258 bp

>AT57658 NZ_CP012997:c842840-842583 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCTTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATA
TCAAAATGGTTGAAATAA