Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 830294..830853 Replicon chromosome
Accession NZ_CP012997
Organism Vibrio cholerae strain 2012Env-9

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag NH62_RS03725 Protein ID WP_000578476.1
Coordinates 830575..830853 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag NH62_RS03720 Protein ID WP_000381183.1
Coordinates 830294..830578 (+) Length 95 a.a.

Genomic Context

NH62_RS03695NH62_RS03720NH62_RS03725NH62_RS03690NH62_RS03710NH62_RS03715NH62_RS03730NH62_RS19830NH62_RS03735NH62_RS03740NH62_RS19835NH62_RS03745NH62_RS03750NH62_RS03755NH62_RS03760
Location: 826370..826957 (588 bp)
Type: Others
Protein ID: WP_001131372.1
Location: 830294..830578 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
Location: 830575..830853 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 825505..826134 (630 bp)
Type: Others
Protein ID: WP_001284008.1
Location: 828988..829401 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 829585..830100 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 830992..831387 (396 bp)
Type: Others
Protein ID: WP_001000868.1
Location: 831638..831763 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 832062..832583 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 832577..832846 (270 bp)
Type: Others
Protein ID: WP_001114075.1
Location: 832877..832981 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 833038..833637 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 833787..834659 (873 bp)
Type: Others
Protein ID: WP_000254717.1
Location: 834834..835052 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 835116..835553 (438 bp)
Type: Others
Protein ID: WP_000503169.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NH62_RS03690825505..826134-630WP_001284008.1DnaJ domain-containing protein-
NH62_RS03695826370..826957+588WP_001131372.1DUF2238 domain-containing protein-
NH62_RS03710828988..829401-414WP_000049420.1VOC family protein-
NH62_RS03715829585..830100-516WP_000343779.1GNAT family N-acetyltransferase-
NH62_RS03720830294..830578+285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
NH62_RS03725830575..830853+279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
NH62_RS03730830992..831387-396WP_001000868.1hypothetical protein-
NH62_RS19830831638..831763-126WP_001905700.1DUF645 family protein-
NH62_RS03735832062..832583-522WP_000921691.1DUF2442 domain-containing protein-
NH62_RS03740832577..832846-270WP_001114075.1DUF4160 domain-containing protein-
NH62_RS19835832877..832981-105WP_099607150.1acetyltransferase-
NH62_RS03745833038..833637-600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
NH62_RS03750833787..834659-873WP_000254717.1DUF3800 domain-containing protein-
NH62_RS03755834834..835052-219WP_071908318.1GNAT family N-acetyltransferase-
NH62_RS03760835116..835553-438WP_000503169.1IS200/IS605-like element IS1004 family transposase-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-827256..947647120391
flankIS/Tn--835116..835553437
-insideIntegron--828501..941266112765


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T57653 WP_000578476.1 NZ_CP012997:830575-830853 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T57653 NZ_CP012997:830575-830853 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT57653 WP_000381183.1 NZ_CP012997:830294-830578 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT57653 NZ_CP012997:830294-830578 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A067BL33

References