Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 830294..830853 Replicon chromosome
Accession NZ_CP012997
Organism Vibrio cholerae strain 2012Env-9

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag NH62_RS03725 Protein ID WP_000578476.1
Coordinates 830575..830853 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag NH62_RS03720 Protein ID WP_000381183.1
Coordinates 830294..830578 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NH62_RS03690 825505..826134 - 630 WP_001284008.1 DnaJ domain-containing protein -
NH62_RS03695 826370..826957 + 588 WP_001131372.1 DUF2238 domain-containing protein -
NH62_RS03710 828988..829401 - 414 WP_000049420.1 VOC family protein -
NH62_RS03715 829585..830100 - 516 WP_000343779.1 GNAT family N-acetyltransferase -
NH62_RS03720 830294..830578 + 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NH62_RS03725 830575..830853 + 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
NH62_RS03730 830992..831387 - 396 WP_001000868.1 hypothetical protein -
NH62_RS19830 831638..831763 - 126 WP_001905700.1 DUF645 family protein -
NH62_RS03735 832062..832583 - 522 WP_000921691.1 DUF2442 domain-containing protein -
NH62_RS03740 832577..832846 - 270 WP_001114075.1 DUF4160 domain-containing protein -
NH62_RS19835 832877..832981 - 105 WP_099607150.1 acetyltransferase -
NH62_RS03745 833038..833637 - 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
NH62_RS03750 833787..834659 - 873 WP_000254717.1 DUF3800 domain-containing protein -
NH62_RS03755 834834..835052 - 219 WP_071908318.1 GNAT family N-acetyltransferase -
NH62_RS03760 835116..835553 - 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 827256..947647 120391
flank IS/Tn - - 835116..835553 437
- inside Integron - - 828501..941266 112765


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T57653 WP_000578476.1 NZ_CP012997:830575-830853 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T57653 NZ_CP012997:830575-830853 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT57653 WP_000381183.1 NZ_CP012997:830294-830578 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT57653 NZ_CP012997:830294-830578 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References