Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 1393484..1393855 Replicon chromosome
Accession NZ_CP012127
Organism Escherichia coli strain DH1Ec169

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag ADZ28_RS06920 Protein ID WP_001317028.1
Coordinates 1393661..1393855 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 1393484..1393662 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ADZ28_RS06895 1389439..1390812 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
ADZ28_RS06900 1390941..1391876 - 936 WP_001157406.1 tRNA 2-thiocytidine(32) synthetase TtcA -
ADZ28_RS23435 1391928..1393163 - 1236 WP_000040852.1 site-specific integrase -
ADZ28_RS06910 1393165..1393380 - 216 WP_000079604.1 excisionase XisR -
ADZ28_RS06915 1393459..1393668 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
- 1393484..1393662 + 179 NuclAT_0 - Antitoxin
- 1393484..1393662 + 179 NuclAT_0 - Antitoxin
- 1393484..1393662 + 179 NuclAT_0 - Antitoxin
- 1393484..1393662 + 179 NuclAT_0 - Antitoxin
ADZ28_RS06920 1393661..1393855 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
ADZ28_RS06925 1393912..1394721 - 810 WP_000166319.1 recombination protein RecT -
ADZ28_RS06930 1394714..1397314 - 2601 WP_000105143.1 exodeoxyribonuclease VIII -
ADZ28_RS06935 1397416..1397691 - 276 WP_000632297.1 protein RacC -
ADZ28_RS06940 1397766..1397936 - 171 WP_001352098.1 conserved protein, Rac prophage -
ADZ28_RS06945 1397936..1398157 - 222 WP_000560225.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1391928..1413602 21674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T55920 WP_001317028.1 NZ_CP012127:c1393855-1393661 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

>T55920 NZ_CP012127:c1393855-1393661 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 179 bp

>AT55920 NZ_CP012127:1393484-1393662 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References