Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 1394484..1394855 Replicon chromosome
Accession NZ_CP011343
Organism Escherichia coli K-12 substr. GM4792

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag U069_RS06965 Protein ID WP_001317028.1
Coordinates 1394661..1394855 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 1394484..1394662 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
U069_RS06940 1390439..1391812 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
U069_RS06945 1391941..1392876 - 936 WP_001157406.1 tRNA 2-thiocytidine(32) synthetase TtcA -
U069_RS23465 1392928..1394163 - 1236 WP_000040852.1 site-specific integrase -
U069_RS06955 1394165..1394380 - 216 WP_000079604.1 excisionase XisR -
U069_RS06960 1394459..1394668 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
- 1394484..1394662 + 179 NuclAT_0 - Antitoxin
- 1394484..1394662 + 179 NuclAT_0 - Antitoxin
- 1394484..1394662 + 179 NuclAT_0 - Antitoxin
- 1394484..1394662 + 179 NuclAT_0 - Antitoxin
U069_RS06965 1394661..1394855 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
U069_RS06970 1394912..1395721 - 810 WP_000166319.1 recombination protein RecT -
U069_RS06975 1395714..1398314 - 2601 WP_000105143.1 exodeoxyribonuclease VIII -
U069_RS06980 1398416..1398691 - 276 WP_000632297.1 protein RacC -
U069_RS06985 1398766..1398936 - 171 WP_001352098.1 conserved protein, Rac prophage -
U069_RS06990 1398936..1399157 - 222 WP_000560225.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1385669..1414602 28933


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T54093 WP_001317028.1 NZ_CP011343:c1394855-1394661 [Escherichia coli K-12]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

>T54093 NZ_CP011343:c1394855-1394661 [Escherichia coli K-12]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 179 bp

>AT54093 NZ_CP011343:1394484-1394662 [Escherichia coli K-12]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References