Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 1406043..1406414 Replicon chromosome
Accession NZ_CP011324
Organism Escherichia coli strain SQ2203

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag CS35_RS07035 Protein ID WP_001317028.1
Coordinates 1406220..1406414 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 1406043..1406221 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CS35_RS07010 1401998..1403371 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
CS35_RS07015 1403500..1404435 - 936 WP_001157406.1 tRNA 2-thiocytidine(32) synthetase TtcA -
CS35_RS23535 1404487..1405722 - 1236 WP_000040852.1 site-specific integrase -
CS35_RS07025 1405724..1405939 - 216 WP_000079604.1 excisionase XisR -
CS35_RS07030 1406018..1406227 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
- 1406043..1406221 + 179 NuclAT_0 - Antitoxin
- 1406043..1406221 + 179 NuclAT_0 - Antitoxin
- 1406043..1406221 + 179 NuclAT_0 - Antitoxin
- 1406043..1406221 + 179 NuclAT_0 - Antitoxin
CS35_RS07035 1406220..1406414 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
CS35_RS07040 1406471..1407280 - 810 WP_000166319.1 recombination protein RecT -
CS35_RS07045 1407273..1409873 - 2601 WP_000105143.1 exodeoxyribonuclease VIII -
CS35_RS07050 1409975..1410250 - 276 WP_000632297.1 protein RacC -
CS35_RS07055 1410325..1410495 - 171 WP_001352098.1 conserved protein, Rac prophage -
CS35_RS07060 1410495..1410716 - 222 WP_000560225.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1404487..1426161 21674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T53967 WP_001317028.1 NZ_CP011324:c1406414-1406220 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

>T53967 NZ_CP011324:c1406414-1406220 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 179 bp

>AT53967 NZ_CP011324:1406043-1406221 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References