Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 1406042..1406413 Replicon chromosome
Accession NZ_CP011322
Organism Escherichia coli strain SQ110

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag SG46_RS06880 Protein ID WP_001317028.1
Coordinates 1406219..1406413 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 1406042..1406220 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SG46_RS06855 1401997..1403370 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
SG46_RS06860 1403499..1404434 - 936 WP_001157406.1 tRNA 2-thiocytidine(32) synthetase TtcA -
SG46_RS06865 1404486..1405721 - 1236 WP_000040852.1 site-specific integrase -
SG46_RS06870 1405723..1405938 - 216 WP_000079604.1 excisionase XisR -
SG46_RS06875 1406017..1406226 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
- 1406042..1406220 + 179 NuclAT_0 - Antitoxin
- 1406042..1406220 + 179 NuclAT_0 - Antitoxin
- 1406042..1406220 + 179 NuclAT_0 - Antitoxin
- 1406042..1406220 + 179 NuclAT_0 - Antitoxin
SG46_RS06880 1406219..1406413 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
SG46_RS06885 1406470..1407279 - 810 WP_000166319.1 recombination protein RecT -
SG46_RS06890 1407272..1409872 - 2601 WP_000105143.1 exodeoxyribonuclease VIII -
SG46_RS06895 1409974..1410249 - 276 WP_000632297.1 protein RacC -
SG46_RS06900 1410324..1410494 - 171 WP_001352098.1 conserved protein, Rac prophage -
SG46_RS06905 1410494..1410715 - 222 WP_000560225.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1404486..1426160 21674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T53924 WP_001317028.1 NZ_CP011322:c1406413-1406219 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

>T53924 NZ_CP011322:c1406413-1406219 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 179 bp

>AT53924 NZ_CP011322:1406042-1406220 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References