Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | ralRA/- |
Location | 2154038..2154409 | Replicon | chromosome |
Accession | NZ_CP010439 | ||
Organism | Escherichia coli K-12 strain K-12 MG1655 |
Toxin (Protein)
Gene name | ralR | Uniprot ID | F4VC37 |
Locus tag | SH02_RS10740 | Protein ID | WP_001317028.1 |
Coordinates | 2154215..2154409 (-) | Length | 65 a.a. |
Antitoxin (RNA)
Gene name | ralA | ||
Locus tag | - | ||
Coordinates | 2154038..2154216 (+) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
SH02_RS10715 | 2149993..2151366 | + | 1374 | WP_000123737.1 | ATP-dependent RNA helicase DbpA | - |
SH02_RS10720 | 2151495..2152430 | - | 936 | WP_001157406.1 | tRNA 2-thiocytidine(32) synthetase TtcA | - |
SH02_RS23995 | 2152482..2153717 | - | 1236 | WP_000040852.1 | site-specific integrase | - |
SH02_RS10730 | 2153719..2153934 | - | 216 | WP_000079604.1 | excisionase XisR | - |
SH02_RS10735 | 2154013..2154222 | - | 210 | WP_000276809.1 | double-strand break reduction protein RcbA | - |
- | 2154038..2154216 | + | 179 | NuclAT_0 | - | Antitoxin |
- | 2154038..2154216 | + | 179 | NuclAT_0 | - | Antitoxin |
- | 2154038..2154216 | + | 179 | NuclAT_0 | - | Antitoxin |
- | 2154038..2154216 | + | 179 | NuclAT_0 | - | Antitoxin |
SH02_RS10740 | 2154215..2154409 | - | 195 | WP_001317028.1 | type I toxin-antitoxin system endodeoxyribonuclease toxin RalR | Toxin |
SH02_RS10745 | 2154466..2155275 | - | 810 | WP_000166319.1 | recombination protein RecT | - |
SH02_RS10750 | 2155268..2157868 | - | 2601 | WP_000105143.1 | exodeoxyribonuclease VIII | - |
SH02_RS10755 | 2157970..2158245 | - | 276 | WP_000632297.1 | protein RacC | - |
SH02_RS10760 | 2158320..2158490 | - | 171 | WP_001352098.1 | conserved protein, Rac prophage | - |
SH02_RS10765 | 2158490..2158711 | - | 222 | WP_000560225.1 | killing protein KilR | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Prophage | - | - | 2145223..2174155 | 28932 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 65 a.a. Molecular weight: 7018.89 Da Isoelectric Point: 8.9538
>T52463 WP_001317028.1 NZ_CP010439:c2154409-2154215 [Escherichia coli K-12]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV
Download Length: 195 bp
>T52463 NZ_CP010439:c2154409-2154215 [Escherichia coli K-12]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA
Antitoxin
Download Length: 179 bp
>AT52463 NZ_CP010439:2154038-2154216 [Escherichia coli K-12]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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