Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 1393986..1394357 Replicon chromosome
Accession NZ_CP009644
Organism Escherichia coli ER2796 strain K-12 ER2796

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag ER2796_RS06975 Protein ID WP_001317028.1
Coordinates 1394163..1394357 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 1393986..1394164 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ER2796_RS06950 1389941..1391314 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
ER2796_RS06955 1391443..1392378 - 936 WP_001157406.1 tRNA 2-thiocytidine(32) synthetase TtcA -
ER2796_RS23370 1392430..1393665 - 1236 WP_000040852.1 site-specific integrase -
ER2796_RS06965 1393667..1393882 - 216 WP_000079604.1 excisionase XisR -
ER2796_RS06970 1393961..1394170 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
- 1393986..1394164 + 179 NuclAT_0 - Antitoxin
- 1393986..1394164 + 179 NuclAT_0 - Antitoxin
- 1393986..1394164 + 179 NuclAT_0 - Antitoxin
- 1393986..1394164 + 179 NuclAT_0 - Antitoxin
ER2796_RS06975 1394163..1394357 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
ER2796_RS06980 1394414..1395223 - 810 WP_000166319.1 recombination protein RecT -
ER2796_RS06985 1395216..1397816 - 2601 WP_000105143.1 exodeoxyribonuclease VIII -
ER2796_RS06990 1397918..1398193 - 276 WP_000632297.1 protein RacC -
ER2796_RS06995 1398268..1398438 - 171 WP_001352098.1 conserved protein, Rac prophage -
ER2796_RS07000 1398438..1398659 - 222 WP_000560225.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1385171..1414103 28932


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T49358 WP_001317028.1 NZ_CP009644:c1394357-1394163 [Escherichia coli ER2796]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

>T49358 NZ_CP009644:c1394357-1394163 [Escherichia coli ER2796]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 179 bp

>AT49358 NZ_CP009644:1393986-1394164 [Escherichia coli ER2796]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References