Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 83391..84175 Replicon chromosome
Accession NZ_AP024556
Organism Vibrio cholerae strain IDH-03506

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag K6J79_RS14525 Protein ID WP_001114075.1
Coordinates 83391..83660 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag K6J79_RS14530 Protein ID WP_000921691.1
Coordinates 83654..84175 (+) Length 174 a.a.

Genomic Context

K6J79_RS14485K6J79_RS14490K6J79_RS14495K6J79_RS14500K6J79_RS14505K6J79_RS14510K6J79_RS14515K6J79_RS14520K6J79_RS14525K6J79_RS14530K6J79_RS14535K6J79_RS14540K6J79_RS14555K6J79_RS14560K6J79_RS14565K6J79_RS14545K6J79_RS14550
Location: 78757..79674 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 79831..80220 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 80356..80565 (210 bp)
Type: Others
Protein ID: Protein_168
Location: 80684..81121 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 81182..81403 (222 bp)
Type: Others
Protein ID: Protein_170
Location: 81578..82450 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 82600..83199 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 83256..83324 (69 bp)
Type: Others
Protein ID: Protein_173
Location: 83391..83660 (270 bp)
Type: Toxin
Protein ID: WP_001114075.1
Location: 83654..84175 (522 bp)
Type: Antitoxin
Protein ID: WP_000921691.1
Location: 84474..84599 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 84850..85245 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 86136..86651 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 86835..87248 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 87803..88979 (1177 bp)
Type: Others
Protein ID: WP_086014537.1
Location: 85384..85661 (278 bp)
Type: Others
Protein ID: Protein_178
Location: 85658..85942 (285 bp)
Type: Others
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K6J79_RS1448578757..79674+918WP_000186333.1alpha/beta hydrolase-
K6J79_RS1449079831..80220+390WP_001081302.1hypothetical protein-
K6J79_RS1449580356..80565+210Protein_168GNAT family N-acetyltransferase-
K6J79_RS1450080684..81121+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
K6J79_RS1450581182..81403+222Protein_170GNAT family N-acetyltransferase-
K6J79_RS1451081578..82450+873WP_000254716.1DUF3800 domain-containing protein-
K6J79_RS1451582600..83199+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
K6J79_RS1452083256..83324+69Protein_173acetyltransferase-
K6J79_RS1452583391..83660+270WP_001114075.1DUF4160 domain-containing proteinToxin
K6J79_RS1453083654..84175+522WP_000921691.1DUF2442 domain-containing proteinAntitoxin
K6J79_RS1453584474..84599+126WP_001905700.1DUF645 family protein-
K6J79_RS1454084850..85245+396WP_001000867.1hypothetical protein-
K6J79_RS1454585384..85661-278Protein_178type II toxin-antitoxin system RelE/ParE family toxin-
K6J79_RS1455085658..85942-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
K6J79_RS1455586136..86651+516WP_000343779.1GNAT family protein-
K6J79_RS1456086835..87248+414WP_000049420.1VOC family protein-
K6J79_RS1456587803..88979+1177WP_086014537.1IS3-like element ISVch4 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegron-cqsA / ugd / htpB / hlyA / hcp-2 / vgrG-2 / vipA/mglA / vipB/mglB / VCA0109 / vasA / vasB / vasC / vasD / vasE / vasF / clpB/vasG / vasH / vasI / vasJ / icmF/vasK / vasL / vgrG-3 / hlyA3..10619581061955
flankIS/Tn--80684..81121437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T38700 WP_001114075.1 NZ_AP024556:83391-83660 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T38700 NZ_AP024556:83391-83660 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT38700 WP_000921691.1 NZ_AP024556:83654-84175 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT38700 NZ_AP024556:83654-84175 [Vibrio cholerae]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAGCACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A086SLD6

Antitoxin

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Source
ID
Structure
AlphaFold DBQ9KM84

References