38700

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 83391..84175 Replicon chromosome
Accession NZ_AP024556
Organism Vibrio cholerae strain IDH-03506

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag K6J79_RS14525 Protein ID WP_001114075.1
Coordinates 83391..83660 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag K6J79_RS14530 Protein ID WP_000921691.1
Coordinates 83654..84175 (+) Length 174 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J79_RS14485 78757..79674 + 918 WP_000186333.1 alpha/beta hydrolase -
K6J79_RS14490 79831..80220 + 390 WP_001081302.1 hypothetical protein -
K6J79_RS14495 80356..80565 + 210 Protein_168 GNAT family N-acetyltransferase -
K6J79_RS14500 80684..81121 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
K6J79_RS14505 81182..81403 + 222 Protein_170 GNAT family N-acetyltransferase -
K6J79_RS14510 81578..82450 + 873 WP_000254716.1 DUF3800 domain-containing protein -
K6J79_RS14515 82600..83199 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
K6J79_RS14520 83256..83324 + 69 Protein_173 acetyltransferase -
K6J79_RS14525 83391..83660 + 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
K6J79_RS14530 83654..84175 + 522 WP_000921691.1 DUF2442 domain-containing protein Antitoxin
K6J79_RS14535 84474..84599 + 126 WP_001905700.1 DUF645 family protein -
K6J79_RS14540 84850..85245 + 396 WP_001000867.1 hypothetical protein -
K6J79_RS14545 85384..85661 - 278 Protein_178 type II toxin-antitoxin system RelE/ParE family toxin -
K6J79_RS14550 85658..85942 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
K6J79_RS14555 86136..86651 + 516 WP_000343779.1 GNAT family protein -
K6J79_RS14560 86835..87248 + 414 WP_000049420.1 VOC family protein -
K6J79_RS14565 87803..88979 + 1177 WP_086014537.1 IS3-like element ISVch4 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - cqsA / ugd / htpB / hlyA / hcp-2 / vgrG-2 / vipA/mglA / vipB/mglB / VCA0109 / vasA / vasB / vasC / vasD / vasE / vasF / clpB/vasG / vasH / vasI / vasJ / icmF/vasK / vasL / vgrG-3 / hlyA 3..1061958 1061955
flank IS/Tn - - 80684..81121 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T38700 WP_001114075.1 NZ_AP024556:83391-83660 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T38700 NZ_AP024556:83391-83660 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT38700 WP_000921691.1 NZ_AP024556:83654-84175 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT38700 NZ_AP024556:83654-84175 [Vibrio cholerae]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAGCACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure
AlphaFold DB Q9KM84

References