Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 76975..77774 Replicon chromosome
Accession NZ_AP024556
Organism Vibrio cholerae strain IDH-03506

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag K6J79_RS14470 Protein ID WP_000118351.1
Coordinates 77241..77774 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0K9UER4
Locus tag K6J79_RS19030 Protein ID WP_000179600.1
Coordinates 76975..77244 (+) Length 90 a.a.

Genomic Context

K6J79_RS14420K6J79_RS14425K6J79_RS14430K6J79_RS19015K6J79_RS14435K6J79_RS19020K6J79_RS19025K6J79_RS14450K6J79_RS14455K6J79_RS14460K6J79_RS19030K6J79_RS14470K6J79_RS19035K6J79_RS14475K6J79_RS14480K6J79_RS14485K6J79_RS14490K6J79_RS14495K6J79_RS14500K6J79_RS14505K6J79_RS14510K6J79_RS14440K6J79_RS14445
Location: 72350..72601 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 72591..72878 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 73006..73461 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 73518..73640 (123 bp)
Type: Others
Protein ID: Protein_152
Location: 73811..73935 (125 bp)
Type: Others
Protein ID: Protein_153
Location: 74052..74120 (69 bp)
Type: Others
Protein ID: Protein_154
Location: 75054..75116 (63 bp)
Type: Others
Protein ID: Protein_157
Location: 75133..75801 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 75953..76240 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 76381..76752 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 76975..77244 (270 bp)
Type: Antitoxin
Protein ID: WP_000179600.1
Location: 77241..77774 (534 bp)
Type: Toxin
Protein ID: WP_000118351.1
Location: 77784..77894 (111 bp)
Type: Others
Protein ID: WP_086010065.1
Location: 77976..78233 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 78221..78523 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 78757..79674 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 79831..80220 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 80356..80565 (210 bp)
Type: Others
Protein ID: Protein_168
Location: 80684..81121 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 81182..81403 (222 bp)
Type: Others
Protein ID: Protein_170
Location: 81578..82450 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 74137..74633 (497 bp)
Type: Others
Protein ID: Protein_155
Location: 74630..74902 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K6J79_RS1442072350..72601+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
K6J79_RS1442572591..72878+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
K6J79_RS1443073006..73461+456WP_001245327.1GNAT family N-acetyltransferase-
K6J79_RS1901573518..73640+123Protein_152acetyltransferase-
K6J79_RS1443573811..73935+125Protein_153DUF645 family protein-
K6J79_RS1902074052..74120+69Protein_154acetyltransferase-
K6J79_RS1444074137..74633-497Protein_155GNAT family N-acetyltransferase-
K6J79_RS1444574630..74902-273WP_000246253.1DUF1778 domain-containing protein-
K6J79_RS1902575054..75116+63Protein_157acetyltransferase-
K6J79_RS1445075133..75801+669WP_000043871.1hypothetical protein-
K6J79_RS1445575953..76240+288WP_000426470.1hypothetical protein-
K6J79_RS1446076381..76752+372WP_001164080.1MazG nucleotide pyrophosphohydrolase domain-containing protein-
K6J79_RS1903076975..77244+270WP_000179600.1DUF1778 domain-containing proteinAntitoxin
K6J79_RS1447077241..77774+534WP_000118351.1GNAT family N-acetyltransferaseToxin
K6J79_RS1903577784..77894+111WP_086010065.1DUF3265 domain-containing protein-
K6J79_RS1447577976..78233+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
K6J79_RS1448078221..78523+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
K6J79_RS1448578757..79674+918WP_000186333.1alpha/beta hydrolase-
K6J79_RS1449079831..80220+390WP_001081302.1hypothetical protein-
K6J79_RS1449580356..80565+210Protein_168GNAT family N-acetyltransferase-
K6J79_RS1450080684..81121+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
K6J79_RS1450581182..81403+222Protein_170GNAT family N-acetyltransferase-
K6J79_RS1451081578..82450+873WP_000254716.1DUF3800 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegron-cqsA / ugd / htpB / hlyA / hcp-2 / vgrG-2 / vipA/mglA / vipB/mglB / VCA0109 / vasA / vasB / vasC / vasD / vasE / vasF / clpB/vasG / vasH / vasI / vasJ / icmF/vasK / vasL / vgrG-3 / hlyA3..10619581061955
flankIS/Tn--80684..81121437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(5-81)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T38698 WP_000118351.1 NZ_AP024556:77241-77774 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T38698 NZ_AP024556:77241-77774 [Vibrio cholerae]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGCCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATACGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9924.49 Da        Isoelectric Point: 4.9107

>AT38698 WP_000179600.1 NZ_AP024556:76975-77244 [Vibrio cholerae]
MATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAV
KFTEKSGIK

Download         Length: 270 bp

>AT38698 NZ_AP024556:76975-77244 [Vibrio cholerae]
ATGGCAACGGCACGTTTAGATATCCGCCTTGATGAAGAGATCAAGGCAAAAGCTGAAAAGGCATCGGCTTTACTTGGTTT
AAAAAGTCTCACTGAATATGTGGTGAGACTTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGG
TTAAAGACAGTGTTTTTGACGAGTTTATGGCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTT
AAATTTACAGAGAAGAGCGGTATCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM94

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0K9UER4

References