38698

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 76975..77774 Replicon chromosome
Accession NZ_AP024556
Organism Vibrio cholerae strain IDH-03506

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag K6J79_RS14470 Protein ID WP_000118351.1
Coordinates 77241..77774 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0K9UER4
Locus tag K6J79_RS19030 Protein ID WP_000179600.1
Coordinates 76975..77244 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J79_RS14420 72350..72601 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
K6J79_RS14425 72591..72878 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
K6J79_RS14430 73006..73461 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
K6J79_RS19015 73518..73640 + 123 Protein_152 acetyltransferase -
K6J79_RS14435 73811..73935 + 125 Protein_153 DUF645 family protein -
K6J79_RS19020 74052..74120 + 69 Protein_154 acetyltransferase -
K6J79_RS14440 74137..74633 - 497 Protein_155 GNAT family N-acetyltransferase -
K6J79_RS14445 74630..74902 - 273 WP_000246253.1 DUF1778 domain-containing protein -
K6J79_RS19025 75054..75116 + 63 Protein_157 acetyltransferase -
K6J79_RS14450 75133..75801 + 669 WP_000043871.1 hypothetical protein -
K6J79_RS14455 75953..76240 + 288 WP_000426470.1 hypothetical protein -
K6J79_RS14460 76381..76752 + 372 WP_001164080.1 MazG nucleotide pyrophosphohydrolase domain-containing protein -
K6J79_RS19030 76975..77244 + 270 WP_000179600.1 DUF1778 domain-containing protein Antitoxin
K6J79_RS14470 77241..77774 + 534 WP_000118351.1 GNAT family N-acetyltransferase Toxin
K6J79_RS19035 77784..77894 + 111 WP_086010065.1 DUF3265 domain-containing protein -
K6J79_RS14475 77976..78233 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
K6J79_RS14480 78221..78523 + 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin -
K6J79_RS14485 78757..79674 + 918 WP_000186333.1 alpha/beta hydrolase -
K6J79_RS14490 79831..80220 + 390 WP_001081302.1 hypothetical protein -
K6J79_RS14495 80356..80565 + 210 Protein_168 GNAT family N-acetyltransferase -
K6J79_RS14500 80684..81121 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
K6J79_RS14505 81182..81403 + 222 Protein_170 GNAT family N-acetyltransferase -
K6J79_RS14510 81578..82450 + 873 WP_000254716.1 DUF3800 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - cqsA / ugd / htpB / hlyA / hcp-2 / vgrG-2 / vipA/mglA / vipB/mglB / VCA0109 / vasA / vasB / vasC / vasD / vasE / vasF / clpB/vasG / vasH / vasI / vasJ / icmF/vasK / vasL / vgrG-3 / hlyA 3..1061958 1061955
flank IS/Tn - - 80684..81121 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(5-81)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T38698 WP_000118351.1 NZ_AP024556:77241-77774 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T38698 NZ_AP024556:77241-77774 [Vibrio cholerae]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGCCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATACGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9924.49 Da        Isoelectric Point: 4.9107

>AT38698 WP_000179600.1 NZ_AP024556:76975-77244 [Vibrio cholerae]
MATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAV
KFTEKSGIK

Download         Length: 270 bp

>AT38698 NZ_AP024556:76975-77244 [Vibrio cholerae]
ATGGCAACGGCACGTTTAGATATCCGCCTTGATGAAGAGATCAAGGCAAAAGCTGAAAAGGCATCGGCTTTACTTGGTTT
AAAAAGTCTCACTGAATATGTGGTGAGACTTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGG
TTAAAGACAGTGTTTTTGACGAGTTTATGGCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTT
AAATTTACAGAGAAGAGCGGTATCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9KM94

Antitoxin

Source ID Structure
AlphaFold DB A0A0K9UER4

References