Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 72350..72878 Replicon chromosome
Accession NZ_AP024556
Organism Vibrio cholerae strain IDH-03506

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag K6J79_RS14425 Protein ID WP_000221354.1
Coordinates 72591..72878 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag K6J79_RS14420 Protein ID WP_001250179.1
Coordinates 72350..72601 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J79_RS14380 67618..67932 + 315 WP_000071008.1 DNA-binding transcriptional regulator -
K6J79_RS14385 68069..68503 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
K6J79_RS14390 68671..68826 + 156 WP_000751734.1 hypothetical protein -
K6J79_RS14395 68951..69931 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
K6J79_RS14400 69999..70305 + 307 Protein_143 CatB-related O-acetyltransferase -
K6J79_RS19000 70442..70840 + 399 Protein_144 GNAT family N-acetyltransferase -
K6J79_RS19005 70964..71134 + 171 WP_001080654.1 hypothetical protein -
K6J79_RS14410 71134..71535 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
K6J79_RS19010 71538..71648 + 111 WP_082798255.1 DUF3265 domain-containing protein -
K6J79_RS14415 71723..72136 + 414 WP_000049417.1 VOC family protein -
K6J79_RS14420 72350..72601 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K6J79_RS14425 72591..72878 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6J79_RS14430 73006..73461 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
K6J79_RS19015 73518..73640 + 123 Protein_152 acetyltransferase -
K6J79_RS14435 73811..73935 + 125 Protein_153 DUF645 family protein -
K6J79_RS19020 74052..74120 + 69 Protein_154 acetyltransferase -
K6J79_RS14440 74137..74633 - 497 Protein_155 GNAT family N-acetyltransferase -
K6J79_RS14445 74630..74902 - 273 WP_000246253.1 DUF1778 domain-containing protein -
K6J79_RS19025 75054..75116 + 63 Protein_157 acetyltransferase -
K6J79_RS14450 75133..75801 + 669 WP_000043871.1 hypothetical protein -
K6J79_RS14455 75953..76240 + 288 WP_000426470.1 hypothetical protein -
K6J79_RS14460 76381..76752 + 372 WP_001164080.1 MazG nucleotide pyrophosphohydrolase domain-containing protein -
K6J79_RS19030 76975..77244 + 270 WP_000179600.1 DUF1778 domain-containing protein -
K6J79_RS14470 77241..77774 + 534 WP_000118351.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - cqsA / ugd / htpB / hlyA / hcp-2 / vgrG-2 / vipA/mglA / vipB/mglB / VCA0109 / vasA / vasB / vasC / vasD / vasE / vasF / clpB/vasG / vasH / vasI / vasJ / icmF/vasK / vasL / vgrG-3 / hlyA 3..1061958 1061955
flank IS/Tn - - 68951..69931 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T38697 WP_000221354.1 NZ_AP024556:72591-72878 [Vibrio cholerae]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T38697 NZ_AP024556:72591-72878 [Vibrio cholerae]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT38697 WP_001250179.1 NZ_AP024556:72350-72601 [Vibrio cholerae]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT38697 NZ_AP024556:72350-72601 [Vibrio cholerae]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X1KZS6

Antitoxin

Source ID Structure
AlphaFold DB A0A0X1KZS8

References