Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc(toxin)
Location 70964..71535 Replicon chromosome
Accession NZ_AP024556
Organism Vibrio cholerae strain IDH-03506

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag K6J79_RS14410 Protein ID WP_000351248.1
Coordinates 71134..71535 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q8GNG3
Locus tag K6J79_RS19005 Protein ID WP_001080654.1
Coordinates 70964..71134 (+) Length 57 a.a.

Genomic Context

K6J79_RS14355K6J79_RS14360K6J79_RS14365K6J79_RS14370K6J79_RS14375K6J79_RS14380K6J79_RS14385K6J79_RS14390K6J79_RS14400K6J79_RS19000K6J79_RS19005K6J79_RS14410K6J79_RS19010K6J79_RS14415K6J79_RS14420K6J79_RS14425K6J79_RS14430K6J79_RS19015K6J79_RS14435K6J79_RS19020K6J79_RS19025K6J79_RS14450K6J79_RS14455K6J79_RS14395K6J79_RS14440K6J79_RS14445
Location: 66159..66273 (115 bp)
Type: Others
Protein ID: Protein_134
Location: 66282..66503 (222 bp)
Type: Others
Protein ID: WP_032468461.1
Location: 66669..66782 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 66731..66958 (228 bp)
Type: Others
Protein ID: WP_073426587.1
Location: 67299..67631 (333 bp)
Type: Others
Protein ID: WP_000843587.1
Location: 67618..67932 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 68069..68503 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 68671..68826 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 69999..70305 (307 bp)
Type: Others
Protein ID: Protein_143
Location: 70442..70840 (399 bp)
Type: Others
Protein ID: Protein_144
Location: 70964..71134 (171 bp)
Type: Antitoxin
Protein ID: WP_001080654.1
Location: 71134..71535 (402 bp)
Type: Toxin
Protein ID: WP_000351248.1
Location: 71538..71648 (111 bp)
Type: Others
Protein ID: WP_082798255.1
Location: 71723..72136 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 72350..72601 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 72591..72878 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 73006..73461 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 73518..73640 (123 bp)
Type: Others
Protein ID: Protein_152
Location: 73811..73935 (125 bp)
Type: Others
Protein ID: Protein_153
Location: 74052..74120 (69 bp)
Type: Others
Protein ID: Protein_154
Location: 75054..75116 (63 bp)
Type: Others
Protein ID: Protein_157
Location: 75133..75801 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 75953..76240 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 68951..69931 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 74137..74633 (497 bp)
Type: Others
Protein ID: Protein_155
Location: 74630..74902 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K6J79_RS1435566159..66273+115Protein_134acetyltransferase-
K6J79_RS1436066282..66503+222WP_032468461.1DUF1289 domain-containing protein-
K6J79_RS1436566669..66782+114WP_001889158.1hypothetical protein-
K6J79_RS1437066731..66958+228WP_073426587.1DUF1289 domain-containing protein-
K6J79_RS1437567299..67631+333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxin-
K6J79_RS1438067618..67932+315WP_000071008.1DNA-binding transcriptional regulator-
K6J79_RS1438568069..68503+435WP_000256036.1GNAT family N-acetyltransferase-
K6J79_RS1439068671..68826+156WP_000751734.1hypothetical protein-
K6J79_RS1439568951..69931-981WP_000019370.1IS5-like element ISVch5 family transposase-
K6J79_RS1440069999..70305+307Protein_143CatB-related O-acetyltransferase-
K6J79_RS1900070442..70840+399Protein_144GNAT family N-acetyltransferase-
K6J79_RS1900570964..71134+171WP_001080654.1hypothetical proteinAntitoxin
K6J79_RS1441071134..71535+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxinToxin
K6J79_RS1901071538..71648+111WP_082798255.1DUF3265 domain-containing protein-
K6J79_RS1441571723..72136+414WP_000049417.1VOC family protein-
K6J79_RS1442072350..72601+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
K6J79_RS1442572591..72878+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
K6J79_RS1443073006..73461+456WP_001245327.1GNAT family N-acetyltransferase-
K6J79_RS1901573518..73640+123Protein_152acetyltransferase-
K6J79_RS1443573811..73935+125Protein_153DUF645 family protein-
K6J79_RS1902074052..74120+69Protein_154acetyltransferase-
K6J79_RS1444074137..74633-497Protein_155GNAT family N-acetyltransferase-
K6J79_RS1444574630..74902-273WP_000246253.1DUF1778 domain-containing protein-
K6J79_RS1902575054..75116+63Protein_157acetyltransferase-
K6J79_RS1445075133..75801+669WP_000043871.1hypothetical protein-
K6J79_RS1445575953..76240+288WP_000426470.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegron-cqsA / ugd / htpB / hlyA / hcp-2 / vgrG-2 / vipA/mglA / vipB/mglB / VCA0109 / vasA / vasB / vasC / vasD / vasE / vasF / clpB/vasG / vasH / vasI / vasJ / icmF/vasK / vasL / vgrG-3 / hlyA3..10619581061955
flankIS/Tn--68951..69931980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T38696 WP_000351248.1 NZ_AP024556:71134-71535 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T38696 NZ_AP024556:71134-71535 [Vibrio cholerae]
ATGGATATCATCTGTTTTCCTTTTGAACGAGTGATCGAGATTAATGCTTTCATCCTAAAAACAGAACCAGGAATGAAAGG
AGCCGTTGATATTCCCAAGCTTCAGGGGGCATTAGGTCGAATCGATAATGCCATCGTTTATGAAGGACTGGATGATGTTT
TTGAAATCGCTGCTAAATACACTGCTTGTATAGCGGTTTCACATGCGCTACCTGATGCGAACAAACGCACAGGTTTGGCT
GTGGCACTTGAATATTTATCACTTAACGATTTTGAGCTTACGCAGGAAAACGATTTACTTGCGGATGCAGTTCGAGATCT
TGTTATCGGCATTATCAACGAAACAGATTTTGCCGACATTCTCTACGCACAATACGCAAAAGAACAAAATTCAGCTCTCT
AA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6287.35 Da        Isoelectric Point: 10.7274

>AT38696 WP_001080654.1 NZ_AP024556:70964-71134 [Vibrio cholerae]
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 171 bp

>AT38696 NZ_AP024556:70964-71134 [Vibrio cholerae]
ATGAATCGAAAAGTTGAAGCTTACGGCGTTGATGCTGTTGAAAGACCGAAAATTAAGGCTAGTAAAAAGCTTGATTTGAC
TGGTGATGCTGGTCGTCAAATTGTGAAGTCTGAAACTAAACTTGCTTTGCGTACTCATCAGAAGACATTCACTAAATTGG
CTGATATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0PN34

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1T4SJJ1

References