38655

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc(toxin)
Location 688978..689549 Replicon chromosome
Accession NZ_AP024552
Organism Vibrio cholerae strain IDH-02387

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag K6J81_RS17225 Protein ID WP_000351248.1
Coordinates 688978..689379 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q8GNG3
Locus tag K6J81_RS19255 Protein ID WP_001080654.1
Coordinates 689379..689549 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J81_RS17180 684274..684561 - 288 WP_000426470.1 hypothetical protein -
K6J81_RS17185 684713..685381 - 669 WP_000043871.1 hypothetical protein -
K6J81_RS19235 685398..685460 - 63 Protein_597 acetyltransferase -
K6J81_RS17190 685612..685884 + 273 WP_000246253.1 DUF1778 domain-containing protein -
K6J81_RS17195 685881..686376 + 496 Protein_599 GNAT family N-acetyltransferase -
K6J81_RS19240 686393..686461 - 69 Protein_600 acetyltransferase -
K6J81_RS17200 686578..686682 - 105 WP_228840819.1 DUF645 family protein -
K6J81_RS19245 686873..686995 - 123 Protein_602 acetyltransferase -
K6J81_RS17205 687052..687507 - 456 WP_001245327.1 GNAT family N-acetyltransferase -
K6J81_RS17210 687635..687922 - 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
K6J81_RS17215 687912..688163 - 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
K6J81_RS17220 688377..688790 - 414 WP_000049417.1 VOC family protein -
K6J81_RS19250 688865..688975 - 111 WP_082798255.1 DUF3265 domain-containing protein -
K6J81_RS17225 688978..689379 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
K6J81_RS19255 689379..689549 - 171 WP_001080654.1 hypothetical protein Antitoxin
K6J81_RS19260 689673..690071 - 399 Protein_610 GNAT family N-acetyltransferase -
K6J81_RS17235 690208..690514 - 307 Protein_611 CatB-related O-acetyltransferase -
K6J81_RS17240 690582..691562 + 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
K6J81_RS17245 691687..691842 - 156 WP_000751734.1 hypothetical protein -
K6J81_RS17250 692010..692444 - 435 WP_000256036.1 GNAT family N-acetyltransferase -
K6J81_RS17255 692581..692895 - 315 WP_000071008.1 DNA-binding transcriptional regulator -
K6J81_RS17260 692882..693214 - 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin -
K6J81_RS17265 693555..693782 - 228 WP_001894457.1 DUF1289 domain-containing protein -
K6J81_RS17270 693731..693844 - 114 WP_001889158.1 hypothetical protein -
K6J81_RS17275 694010..694231 - 222 WP_032468461.1 DUF1289 domain-containing protein -
K6J81_RS17280 694240..694354 - 115 Protein_620 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 665280..687507 22227
- inside Integron - - 672778..725906 53128
flank IS/Tn - - 690582..691562 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T38655 WP_000351248.1 NZ_AP024552:c689379-688978 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T38655 NZ_AP024552:c689379-688978 [Vibrio cholerae]
ATGGATATCATCTGTTTTCCTTTTGAACGAGTGATCGAGATTAATGCTTTCATCCTAAAAACAGAACCAGGAATGAAAGG
AGCCGTTGATATTCCCAAGCTTCAGGGGGCATTAGGTCGAATCGATAATGCCATCGTTTATGAAGGACTGGATGATGTTT
TTGAAATCGCTGCTAAATACACTGCTTGTATAGCGGTTTCACATGCGCTACCTGATGCGAACAAACGCACAGGTTTGGCT
GTGGCACTTGAATATTTATCACTTAACGATTTTGAGCTTACGCAGGAAAACGATTTACTTGCGGATGCAGTTCGAGATCT
TGTTATCGGCATTATCAACGAAACAGATTTTGCCGACATTCTCTACGCACAATACGCAAAAGAACAAAATTCAGCTCTCT
AA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6287.35 Da        Isoelectric Point: 10.7274

>AT38655 WP_001080654.1 NZ_AP024552:c689549-689379 [Vibrio cholerae]
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 171 bp

>AT38655 NZ_AP024552:c689549-689379 [Vibrio cholerae]
ATGAATCGAAAAGTTGAAGCTTACGGCGTTGATGCTGTTGAAAGACCGAAAATTAAGGCTAGTAAAAAGCTTGATTTGAC
TGGTGATGCTGGTCGTCAAATTGTGAAGTCTGAAACTAAACTTGCTTTGCGTACTCATCAGAAGACATTCACTAAATTGG
CTGATATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0PN34

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SJJ1

References