Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 682740..683539 Replicon chromosome
Accession NZ_AP024552
Organism Vibrio cholerae strain IDH-02387

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag K6J81_RS17165 Protein ID WP_000118351.1
Coordinates 682740..683273 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0K9UER4
Locus tag K6J81_RS19230 Protein ID WP_000179600.1
Coordinates 683270..683539 (-) Length 90 a.a.

Genomic Context

K6J81_RS17190K6J81_RS17195K6J81_RS17125K6J81_RS17130K6J81_RS17135K6J81_RS17140K6J81_RS17145K6J81_RS17150K6J81_RS17155K6J81_RS17160K6J81_RS19225K6J81_RS17165K6J81_RS19230K6J81_RS17175K6J81_RS17180K6J81_RS17185K6J81_RS19235K6J81_RS19240K6J81_RS17200K6J81_RS19245K6J81_RS17205K6J81_RS17210K6J81_RS17215
Location: 685612..685884 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 685881..686376 (496 bp)
Type: Others
Protein ID: Protein_599
Location: 678064..678936 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 679111..679332 (222 bp)
Type: Others
Protein ID: Protein_584
Location: 679393..679830 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 679949..680158 (210 bp)
Type: Others
Protein ID: Protein_586
Location: 680294..680683 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 680840..681757 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 681991..682293 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 682281..682538 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 682620..682730 (111 bp)
Type: Others
Protein ID: WP_086010065.1
Location: 682740..683273 (534 bp)
Type: Toxin
Protein ID: WP_000118351.1
Location: 683270..683539 (270 bp)
Type: Antitoxin
Protein ID: WP_000179600.1
Location: 683762..684133 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 684274..684561 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 684713..685381 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 685398..685460 (63 bp)
Type: Others
Protein ID: Protein_597
Location: 686393..686461 (69 bp)
Type: Others
Protein ID: Protein_600
Location: 686578..686682 (105 bp)
Type: Others
Protein ID: WP_228840819.1
Location: 686873..686995 (123 bp)
Type: Others
Protein ID: Protein_602
Location: 687052..687507 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 687635..687922 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 687912..688163 (252 bp)
Type: Others
Protein ID: WP_001250179.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K6J81_RS17125678064..678936-873WP_000254716.1DUF3800 domain-containing protein-
K6J81_RS17130679111..679332-222Protein_584GNAT family N-acetyltransferase-
K6J81_RS17135679393..679830-438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
K6J81_RS17140679949..680158-210Protein_586GNAT family N-acetyltransferase-
K6J81_RS17145680294..680683-390WP_001081302.1hypothetical protein-
K6J81_RS17150680840..681757-918WP_000186333.1alpha/beta hydrolase-
K6J81_RS17155681991..682293-303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
K6J81_RS17160682281..682538-258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
K6J81_RS19225682620..682730-111WP_086010065.1DUF3265 domain-containing protein-
K6J81_RS17165682740..683273-534WP_000118351.1GNAT family N-acetyltransferaseToxin
K6J81_RS19230683270..683539-270WP_000179600.1DUF1778 domain-containing proteinAntitoxin
K6J81_RS17175683762..684133-372WP_001164080.1MazG nucleotide pyrophosphohydrolase domain-containing protein-
K6J81_RS17180684274..684561-288WP_000426470.1hypothetical protein-
K6J81_RS17185684713..685381-669WP_000043871.1hypothetical protein-
K6J81_RS19235685398..685460-63Protein_597acetyltransferase-
K6J81_RS17190685612..685884+273WP_000246253.1DUF1778 domain-containing protein-
K6J81_RS17195685881..686376+496Protein_599GNAT family N-acetyltransferase-
K6J81_RS19240686393..686461-69Protein_600acetyltransferase-
K6J81_RS17200686578..686682-105WP_228840819.1DUF645 family protein-
K6J81_RS19245686873..686995-123Protein_602acetyltransferase-
K6J81_RS17205687052..687507-456WP_001245327.1GNAT family N-acetyltransferase-
K6J81_RS17210687635..687922-288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
K6J81_RS17215687912..688163-252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--665280..68750722227
-insideIntegron--672778..72590653128
flankIS/Tn--679393..679830437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(5-81)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T38653 WP_000118351.1 NZ_AP024552:c683273-682740 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T38653 NZ_AP024552:c683273-682740 [Vibrio cholerae]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGCCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATACGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9924.49 Da        Isoelectric Point: 4.9107

>AT38653 WP_000179600.1 NZ_AP024552:c683539-683270 [Vibrio cholerae]
MATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAV
KFTEKSGIK

Download         Length: 270 bp

>AT38653 NZ_AP024552:c683539-683270 [Vibrio cholerae]
ATGGCAACGGCACGTTTAGATATCCGCCTTGATGAAGAGATCAAGGCAAAAGCTGAAAAGGCATCGGCTTTACTTGGTTT
AAAAAGTCTCACTGAATATGTGGTGAGACTTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGG
TTAAAGACAGTGTTTTTGACGAGTTTATGGCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTT
AAATTTACAGAGAAGAGCGGTATCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBQ9KM94

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A0K9UER4

References