38653

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 682740..683539 Replicon chromosome
Accession NZ_AP024552
Organism Vibrio cholerae strain IDH-02387

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag K6J81_RS17165 Protein ID WP_000118351.1
Coordinates 682740..683273 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0K9UER4
Locus tag K6J81_RS19230 Protein ID WP_000179600.1
Coordinates 683270..683539 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J81_RS17125 678064..678936 - 873 WP_000254716.1 DUF3800 domain-containing protein -
K6J81_RS17130 679111..679332 - 222 Protein_584 GNAT family N-acetyltransferase -
K6J81_RS17135 679393..679830 - 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
K6J81_RS17140 679949..680158 - 210 Protein_586 GNAT family N-acetyltransferase -
K6J81_RS17145 680294..680683 - 390 WP_001081302.1 hypothetical protein -
K6J81_RS17150 680840..681757 - 918 WP_000186333.1 alpha/beta hydrolase -
K6J81_RS17155 681991..682293 - 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin -
K6J81_RS17160 682281..682538 - 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
K6J81_RS19225 682620..682730 - 111 WP_086010065.1 DUF3265 domain-containing protein -
K6J81_RS17165 682740..683273 - 534 WP_000118351.1 GNAT family N-acetyltransferase Toxin
K6J81_RS19230 683270..683539 - 270 WP_000179600.1 DUF1778 domain-containing protein Antitoxin
K6J81_RS17175 683762..684133 - 372 WP_001164080.1 MazG nucleotide pyrophosphohydrolase domain-containing protein -
K6J81_RS17180 684274..684561 - 288 WP_000426470.1 hypothetical protein -
K6J81_RS17185 684713..685381 - 669 WP_000043871.1 hypothetical protein -
K6J81_RS19235 685398..685460 - 63 Protein_597 acetyltransferase -
K6J81_RS17190 685612..685884 + 273 WP_000246253.1 DUF1778 domain-containing protein -
K6J81_RS17195 685881..686376 + 496 Protein_599 GNAT family N-acetyltransferase -
K6J81_RS19240 686393..686461 - 69 Protein_600 acetyltransferase -
K6J81_RS17200 686578..686682 - 105 WP_228840819.1 DUF645 family protein -
K6J81_RS19245 686873..686995 - 123 Protein_602 acetyltransferase -
K6J81_RS17205 687052..687507 - 456 WP_001245327.1 GNAT family N-acetyltransferase -
K6J81_RS17210 687635..687922 - 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
K6J81_RS17215 687912..688163 - 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 665280..687507 22227
- inside Integron - - 672778..725906 53128
flank IS/Tn - - 679393..679830 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(5-81)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T38653 WP_000118351.1 NZ_AP024552:c683273-682740 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T38653 NZ_AP024552:c683273-682740 [Vibrio cholerae]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGCCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATACGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9924.49 Da        Isoelectric Point: 4.9107

>AT38653 WP_000179600.1 NZ_AP024552:c683539-683270 [Vibrio cholerae]
MATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAV
KFTEKSGIK

Download         Length: 270 bp

>AT38653 NZ_AP024552:c683539-683270 [Vibrio cholerae]
ATGGCAACGGCACGTTTAGATATCCGCCTTGATGAAGAGATCAAGGCAAAAGCTGAAAAGGCATCGGCTTTACTTGGTTT
AAAAAGTCTCACTGAATATGTGGTGAGACTTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGG
TTAAAGACAGTGTTTTTGACGAGTTTATGGCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTT
AAATTTACAGAGAAGAGCGGTATCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9KM94

Antitoxin

Source ID Structure
AlphaFold DB A0A0K9UER4

References