38651

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 676339..677123 Replicon chromosome
Accession NZ_AP024552
Organism Vibrio cholerae strain IDH-02387

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag K6J81_RS17110 Protein ID WP_001114075.1
Coordinates 676854..677123 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag K6J81_RS17105 Protein ID WP_000921691.1
Coordinates 676339..676860 (-) Length 174 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J81_RS17075 673265..673678 - 414 WP_000049420.1 VOC family protein -
K6J81_RS17080 673862..674377 - 516 WP_000343779.1 GNAT family protein -
K6J81_RS17085 674571..674855 + 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
K6J81_RS17090 674852..675130 + 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
K6J81_RS17095 675269..675664 - 396 WP_001000867.1 hypothetical protein -
K6J81_RS17100 675915..676040 - 126 WP_001905700.1 DUF645 family protein -
K6J81_RS17105 676339..676860 - 522 WP_000921691.1 DUF2442 domain-containing protein Antitoxin
K6J81_RS17110 676854..677123 - 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
K6J81_RS17115 677190..677258 - 69 Protein_581 acetyltransferase -
K6J81_RS17120 677315..677914 - 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
K6J81_RS17125 678064..678936 - 873 WP_000254716.1 DUF3800 domain-containing protein -
K6J81_RS17130 679111..679332 - 222 Protein_584 GNAT family N-acetyltransferase -
K6J81_RS17135 679393..679830 - 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
K6J81_RS17140 679949..680158 - 210 Protein_586 GNAT family N-acetyltransferase -
K6J81_RS17145 680294..680683 - 390 WP_001081302.1 hypothetical protein -
K6J81_RS17150 680840..681757 - 918 WP_000186333.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 665280..687507 22227
- inside Integron - - 672778..725906 53128
flank IS/Tn - - 679393..679830 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T38651 WP_001114075.1 NZ_AP024552:c677123-676854 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T38651 NZ_AP024552:c677123-676854 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT38651 WP_000921691.1 NZ_AP024552:c676860-676339 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT38651 NZ_AP024552:c676860-676339 [Vibrio cholerae]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAGCACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure
AlphaFold DB Q9KM84

References