Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 674571..675130 Replicon chromosome
Accession NZ_AP024552
Organism Vibrio cholerae strain IDH-02387

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag K6J81_RS17090 Protein ID WP_000578476.1
Coordinates 674852..675130 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag K6J81_RS17085 Protein ID WP_000381183.1
Coordinates 674571..674855 (+) Length 95 a.a.

Genomic Context

K6J81_RS17085K6J81_RS17090K6J81_RS17075K6J81_RS17080K6J81_RS17095K6J81_RS17100K6J81_RS17105K6J81_RS17110K6J81_RS17115K6J81_RS17120K6J81_RS17125K6J81_RS17130K6J81_RS17135
Location: 674571..674855 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
Location: 674852..675130 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 673265..673678 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 673862..674377 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 675269..675664 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 675915..676040 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 676339..676860 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 676854..677123 (270 bp)
Type: Others
Protein ID: WP_001114075.1
Location: 677190..677258 (69 bp)
Type: Others
Protein ID: Protein_581
Location: 677315..677914 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 678064..678936 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 679111..679332 (222 bp)
Type: Others
Protein ID: Protein_584
Location: 679393..679830 (438 bp)
Type: Others
Protein ID: WP_000503169.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K6J81_RS17075673265..673678-414WP_000049420.1VOC family protein-
K6J81_RS17080673862..674377-516WP_000343779.1GNAT family protein-
K6J81_RS17085674571..674855+285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
K6J81_RS17090674852..675130+279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
K6J81_RS17095675269..675664-396WP_001000867.1hypothetical protein-
K6J81_RS17100675915..676040-126WP_001905700.1DUF645 family protein-
K6J81_RS17105676339..676860-522WP_000921691.1DUF2442 domain-containing protein-
K6J81_RS17110676854..677123-270WP_001114075.1DUF4160 domain-containing protein-
K6J81_RS17115677190..677258-69Protein_581acetyltransferase-
K6J81_RS17120677315..677914-600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
K6J81_RS17125678064..678936-873WP_000254716.1DUF3800 domain-containing protein-
K6J81_RS17130679111..679332-222Protein_584GNAT family N-acetyltransferase-
K6J81_RS17135679393..679830-438WP_000503169.1IS200/IS605-like element IS1004 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--665280..68750722227
-insideIntegron--672778..72590653128
flankIS/Tn--679393..679830437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T38650 WP_000578476.1 NZ_AP024552:674852-675130 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T38650 NZ_AP024552:674852-675130 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT38650 WP_000381183.1 NZ_AP024552:674571-674855 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT38650 NZ_AP024552:674571-674855 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References