38648

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 883892..884676 Replicon chromosome
Accession NZ_AP024550
Organism Vibrio cholerae strain IDH-00113

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag K6J78_RS17785 Protein ID WP_001114075.1
Coordinates 883892..884161 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag K6J78_RS17790 Protein ID WP_000921691.1
Coordinates 884155..884676 (+) Length 174 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J78_RS17745 879258..880175 + 918 WP_000186333.1 alpha/beta hydrolase -
K6J78_RS17750 880332..880721 + 390 WP_001081302.1 hypothetical protein -
K6J78_RS17755 880857..881066 + 210 Protein_859 GNAT family N-acetyltransferase -
K6J78_RS17760 881185..881622 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
K6J78_RS17765 881683..881904 + 222 Protein_861 GNAT family N-acetyltransferase -
K6J78_RS17770 882079..882951 + 873 WP_000254716.1 DUF3800 domain-containing protein -
K6J78_RS17775 883101..883700 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
K6J78_RS17780 883757..883825 + 69 Protein_864 acetyltransferase -
K6J78_RS17785 883892..884161 + 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
K6J78_RS17790 884155..884676 + 522 WP_000921691.1 DUF2442 domain-containing protein Antitoxin
K6J78_RS17795 884975..885100 + 126 WP_001905700.1 DUF645 family protein -
K6J78_RS17800 885351..885746 + 396 WP_001000867.1 hypothetical protein -
K6J78_RS17805 885885..886162 - 278 Protein_869 type II toxin-antitoxin system RelE/ParE family toxin -
K6J78_RS17810 886159..886443 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
K6J78_RS17815 886637..887152 + 516 WP_000343779.1 GNAT family protein -
K6J78_RS17820 887336..887749 + 414 WP_000049420.1 VOC family protein -
K6J78_RS17825 888304..889480 + 1177 WP_086014537.1 IS3-like element ISVch4 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 782725..888585 105860
flank IS/Tn - - 881185..881622 437
- inside Integron - - 835106..888236 53130


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T38648 WP_001114075.1 NZ_AP024550:883892-884161 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T38648 NZ_AP024550:883892-884161 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT38648 WP_000921691.1 NZ_AP024550:884155-884676 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT38648 NZ_AP024550:884155-884676 [Vibrio cholerae]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAGCACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure
AlphaFold DB Q9KM84

References