Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-Phd |
Location | 878477..879024 | Replicon | chromosome |
Accession | NZ_AP024550 | ||
Organism | Vibrio cholerae strain IDH-00113 |
Toxin (Protein)
Gene name | relE | Uniprot ID | Q9KM92 |
Locus tag | K6J78_RS17740 | Protein ID | WP_000229317.1 |
Coordinates | 878722..879024 (+) | Length | 101 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | Q9KM93 |
Locus tag | K6J78_RS17735 | Protein ID | WP_000861987.1 |
Coordinates | 878477..878734 (+) | Length | 86 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K6J78_RS17690 | 873506..873961 | + | 456 | WP_001245327.1 | GNAT family N-acetyltransferase | - |
K6J78_RS18820 | 874018..874140 | + | 123 | Protein_843 | acetyltransferase | - |
K6J78_RS17695 | 874311..874435 | + | 125 | Protein_844 | DUF645 family protein | - |
K6J78_RS18825 | 874552..874620 | + | 69 | Protein_845 | acetyltransferase | - |
K6J78_RS17700 | 874637..875134 | - | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
K6J78_RS17705 | 875131..875403 | - | 273 | WP_000246253.1 | DUF1778 domain-containing protein | - |
K6J78_RS18830 | 875555..875617 | + | 63 | Protein_848 | acetyltransferase | - |
K6J78_RS17710 | 875634..876302 | + | 669 | WP_000043871.1 | hypothetical protein | - |
K6J78_RS17715 | 876454..876741 | + | 288 | WP_000426470.1 | hypothetical protein | - |
K6J78_RS17720 | 876882..877253 | + | 372 | WP_001164080.1 | MazG nucleotide pyrophosphohydrolase domain-containing protein | - |
K6J78_RS18835 | 877476..877745 | + | 270 | WP_000179600.1 | DUF1778 domain-containing protein | - |
K6J78_RS17730 | 877742..878275 | + | 534 | WP_000118351.1 | GNAT family N-acetyltransferase | - |
K6J78_RS18840 | 878285..878395 | + | 111 | WP_086010065.1 | DUF3265 domain-containing protein | - |
K6J78_RS17735 | 878477..878734 | + | 258 | WP_000861987.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
K6J78_RS17740 | 878722..879024 | + | 303 | WP_000229317.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
K6J78_RS17745 | 879258..880175 | + | 918 | WP_000186333.1 | alpha/beta hydrolase | - |
K6J78_RS17750 | 880332..880721 | + | 390 | WP_001081302.1 | hypothetical protein | - |
K6J78_RS17755 | 880857..881066 | + | 210 | Protein_859 | GNAT family N-acetyltransferase | - |
K6J78_RS17760 | 881185..881622 | + | 438 | WP_000503169.1 | IS200/IS605-like element IS1004 family transposase | - |
K6J78_RS17765 | 881683..881904 | + | 222 | Protein_861 | GNAT family N-acetyltransferase | - |
K6J78_RS17770 | 882079..882951 | + | 873 | WP_000254716.1 | DUF3800 domain-containing protein | - |
K6J78_RS17775 | 883101..883700 | + | 600 | WP_001891245.1 | glutathione S-transferase N-terminal domain-containing protein | - |
K6J78_RS17780 | 883757..883825 | + | 69 | Protein_864 | acetyltransferase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | catB9 | - | 782725..888585 | 105860 | |
flank | IS/Tn | - | - | 881185..881622 | 437 | ||
- | inside | Integron | - | - | 835106..888236 | 53130 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11726.68 Da Isoelectric Point: 5.1972
>T38647 WP_000229317.1 NZ_AP024550:878722-879024 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ
Download Length: 303 bp
>T38647 NZ_AP024550:878722-879024 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG
Antitoxin
Download Length: 86 a.a. Molecular weight: 9647.15 Da Isoelectric Point: 7.3178
>AT38647 WP_000861987.1 NZ_AP024550:878477-878734 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
Download Length: 258 bp
>AT38647 NZ_AP024550:878477-878734 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | Q9KM92 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1T4SLM9 |