38646

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 877476..878275 Replicon chromosome
Accession NZ_AP024550
Organism Vibrio cholerae strain IDH-00113

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag K6J78_RS17730 Protein ID WP_000118351.1
Coordinates 877742..878275 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0K9UER4
Locus tag K6J78_RS18835 Protein ID WP_000179600.1
Coordinates 877476..877745 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J78_RS17680 872850..873101 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
K6J78_RS17685 873091..873378 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
K6J78_RS17690 873506..873961 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
K6J78_RS18820 874018..874140 + 123 Protein_843 acetyltransferase -
K6J78_RS17695 874311..874435 + 125 Protein_844 DUF645 family protein -
K6J78_RS18825 874552..874620 + 69 Protein_845 acetyltransferase -
K6J78_RS17700 874637..875134 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
K6J78_RS17705 875131..875403 - 273 WP_000246253.1 DUF1778 domain-containing protein -
K6J78_RS18830 875555..875617 + 63 Protein_848 acetyltransferase -
K6J78_RS17710 875634..876302 + 669 WP_000043871.1 hypothetical protein -
K6J78_RS17715 876454..876741 + 288 WP_000426470.1 hypothetical protein -
K6J78_RS17720 876882..877253 + 372 WP_001164080.1 MazG nucleotide pyrophosphohydrolase domain-containing protein -
K6J78_RS18835 877476..877745 + 270 WP_000179600.1 DUF1778 domain-containing protein Antitoxin
K6J78_RS17730 877742..878275 + 534 WP_000118351.1 GNAT family N-acetyltransferase Toxin
K6J78_RS18840 878285..878395 + 111 WP_086010065.1 DUF3265 domain-containing protein -
K6J78_RS17735 878477..878734 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
K6J78_RS17740 878722..879024 + 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin -
K6J78_RS17745 879258..880175 + 918 WP_000186333.1 alpha/beta hydrolase -
K6J78_RS17750 880332..880721 + 390 WP_001081302.1 hypothetical protein -
K6J78_RS17755 880857..881066 + 210 Protein_859 GNAT family N-acetyltransferase -
K6J78_RS17760 881185..881622 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
K6J78_RS17765 881683..881904 + 222 Protein_861 GNAT family N-acetyltransferase -
K6J78_RS17770 882079..882951 + 873 WP_000254716.1 DUF3800 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 782725..888585 105860
flank IS/Tn - - 881185..881622 437
- inside Integron - - 835106..888236 53130


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(5-81)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T38646 WP_000118351.1 NZ_AP024550:877742-878275 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T38646 NZ_AP024550:877742-878275 [Vibrio cholerae]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGCCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATACGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9924.49 Da        Isoelectric Point: 4.9107

>AT38646 WP_000179600.1 NZ_AP024550:877476-877745 [Vibrio cholerae]
MATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAV
KFTEKSGIK

Download         Length: 270 bp

>AT38646 NZ_AP024550:877476-877745 [Vibrio cholerae]
ATGGCAACGGCACGTTTAGATATCCGCCTTGATGAAGAGATCAAGGCAAAAGCTGAAAAGGCATCGGCTTTACTTGGTTT
AAAAAGTCTCACTGAATATGTGGTGAGACTTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGG
TTAAAGACAGTGTTTTTGACGAGTTTATGGCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTT
AAATTTACAGAGAAGAGCGGTATCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9KM94

Antitoxin

Source ID Structure
AlphaFold DB A0A0K9UER4

References