Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 877476..878275 Replicon chromosome
Accession NZ_AP024550
Organism Vibrio cholerae strain IDH-00113

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag K6J78_RS17730 Protein ID WP_000118351.1
Coordinates 877742..878275 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0K9UER4
Locus tag K6J78_RS18835 Protein ID WP_000179600.1
Coordinates 877476..877745 (+) Length 90 a.a.

Genomic Context

K6J78_RS17680K6J78_RS17685K6J78_RS17690K6J78_RS18820K6J78_RS17695K6J78_RS18825K6J78_RS18830K6J78_RS17710K6J78_RS17715K6J78_RS17720K6J78_RS18835K6J78_RS17730K6J78_RS18840K6J78_RS17735K6J78_RS17740K6J78_RS17745K6J78_RS17750K6J78_RS17755K6J78_RS17760K6J78_RS17765K6J78_RS17770K6J78_RS17700K6J78_RS17705
Location: 872850..873101 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 873091..873378 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 873506..873961 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 874018..874140 (123 bp)
Type: Others
Protein ID: Protein_843
Location: 874311..874435 (125 bp)
Type: Others
Protein ID: Protein_844
Location: 874552..874620 (69 bp)
Type: Others
Protein ID: Protein_845
Location: 875555..875617 (63 bp)
Type: Others
Protein ID: Protein_848
Location: 875634..876302 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 876454..876741 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 876882..877253 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 877476..877745 (270 bp)
Type: Antitoxin
Protein ID: WP_000179600.1
Location: 877742..878275 (534 bp)
Type: Toxin
Protein ID: WP_000118351.1
Location: 878285..878395 (111 bp)
Type: Others
Protein ID: WP_086010065.1
Location: 878477..878734 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 878722..879024 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 879258..880175 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 880332..880721 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 880857..881066 (210 bp)
Type: Others
Protein ID: Protein_859
Location: 881185..881622 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 881683..881904 (222 bp)
Type: Others
Protein ID: Protein_861
Location: 882079..882951 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 874637..875134 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 875131..875403 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K6J78_RS17680872850..873101+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
K6J78_RS17685873091..873378+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
K6J78_RS17690873506..873961+456WP_001245327.1GNAT family N-acetyltransferase-
K6J78_RS18820874018..874140+123Protein_843acetyltransferase-
K6J78_RS17695874311..874435+125Protein_844DUF645 family protein-
K6J78_RS18825874552..874620+69Protein_845acetyltransferase-
K6J78_RS17700874637..875134-498WP_000982260.1GNAT family N-acetyltransferase-
K6J78_RS17705875131..875403-273WP_000246253.1DUF1778 domain-containing protein-
K6J78_RS18830875555..875617+63Protein_848acetyltransferase-
K6J78_RS17710875634..876302+669WP_000043871.1hypothetical protein-
K6J78_RS17715876454..876741+288WP_000426470.1hypothetical protein-
K6J78_RS17720876882..877253+372WP_001164080.1MazG nucleotide pyrophosphohydrolase domain-containing protein-
K6J78_RS18835877476..877745+270WP_000179600.1DUF1778 domain-containing proteinAntitoxin
K6J78_RS17730877742..878275+534WP_000118351.1GNAT family N-acetyltransferaseToxin
K6J78_RS18840878285..878395+111WP_086010065.1DUF3265 domain-containing protein-
K6J78_RS17735878477..878734+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
K6J78_RS17740878722..879024+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
K6J78_RS17745879258..880175+918WP_000186333.1alpha/beta hydrolase-
K6J78_RS17750880332..880721+390WP_001081302.1hypothetical protein-
K6J78_RS17755880857..881066+210Protein_859GNAT family N-acetyltransferase-
K6J78_RS17760881185..881622+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
K6J78_RS17765881683..881904+222Protein_861GNAT family N-acetyltransferase-
K6J78_RS17770882079..882951+873WP_000254716.1DUF3800 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-782725..888585105860
flankIS/Tn--881185..881622437
-insideIntegron--835106..88823653130


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(5-81)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T38646 WP_000118351.1 NZ_AP024550:877742-878275 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T38646 NZ_AP024550:877742-878275 [Vibrio cholerae]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGCCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATACGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9924.49 Da        Isoelectric Point: 4.9107

>AT38646 WP_000179600.1 NZ_AP024550:877476-877745 [Vibrio cholerae]
MATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAV
KFTEKSGIK

Download         Length: 270 bp

>AT38646 NZ_AP024550:877476-877745 [Vibrio cholerae]
ATGGCAACGGCACGTTTAGATATCCGCCTTGATGAAGAGATCAAGGCAAAAGCTGAAAAGGCATCGGCTTTACTTGGTTT
AAAAAGTCTCACTGAATATGTGGTGAGACTTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGG
TTAAAGACAGTGTTTTTGACGAGTTTATGGCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTT
AAATTTACAGAGAAGAGCGGTATCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM94

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0K9UER4

References