38645

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 874637..875403 Replicon chromosome
Accession NZ_AP024550
Organism Vibrio cholerae strain IDH-00113

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag K6J78_RS17700 Protein ID WP_000982260.1
Coordinates 874637..875134 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag K6J78_RS17705 Protein ID WP_000246253.1
Coordinates 875131..875403 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J78_RS17660 870499..870805 + 307 Protein_834 CatB-related O-acetyltransferase -
K6J78_RS18805 870942..871340 + 399 Protein_835 GNAT family N-acetyltransferase -
K6J78_RS18810 871464..871634 + 171 WP_001080654.1 hypothetical protein -
K6J78_RS17670 871634..872035 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
K6J78_RS18815 872038..872148 + 111 WP_082798255.1 DUF3265 domain-containing protein -
K6J78_RS17675 872223..872636 + 414 WP_000049417.1 VOC family protein -
K6J78_RS17680 872850..873101 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
K6J78_RS17685 873091..873378 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
K6J78_RS17690 873506..873961 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
K6J78_RS18820 874018..874140 + 123 Protein_843 acetyltransferase -
K6J78_RS17695 874311..874435 + 125 Protein_844 DUF645 family protein -
K6J78_RS18825 874552..874620 + 69 Protein_845 acetyltransferase -
K6J78_RS17700 874637..875134 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
K6J78_RS17705 875131..875403 - 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
K6J78_RS18830 875555..875617 + 63 Protein_848 acetyltransferase -
K6J78_RS17710 875634..876302 + 669 WP_000043871.1 hypothetical protein -
K6J78_RS17715 876454..876741 + 288 WP_000426470.1 hypothetical protein -
K6J78_RS17720 876882..877253 + 372 WP_001164080.1 MazG nucleotide pyrophosphohydrolase domain-containing protein -
K6J78_RS18835 877476..877745 + 270 WP_000179600.1 DUF1778 domain-containing protein -
K6J78_RS17730 877742..878275 + 534 WP_000118351.1 GNAT family N-acetyltransferase -
K6J78_RS18840 878285..878395 + 111 WP_086010065.1 DUF3265 domain-containing protein -
K6J78_RS17735 878477..878734 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
K6J78_RS17740 878722..879024 + 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin -
K6J78_RS17745 879258..880175 + 918 WP_000186333.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 782725..888585 105860
flank IS/Tn - - 869451..870431 980
- inside Integron - - 835106..888236 53130


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T38645 WP_000982260.1 NZ_AP024550:c875134-874637 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T38645 NZ_AP024550:c875134-874637 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT38645 WP_000246253.1 NZ_AP024550:c875403-875131 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT38645 NZ_AP024550:c875403-875131 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References