38643

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc(toxin)
Location 871464..872035 Replicon chromosome
Accession NZ_AP024550
Organism Vibrio cholerae strain IDH-00113

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag K6J78_RS17670 Protein ID WP_000351248.1
Coordinates 871634..872035 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q8GNG3
Locus tag K6J78_RS18810 Protein ID WP_001080654.1
Coordinates 871464..871634 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J78_RS17615 866659..866773 + 115 Protein_825 acetyltransferase -
K6J78_RS17620 866782..867003 + 222 WP_032468461.1 DUF1289 domain-containing protein -
K6J78_RS17625 867169..867282 + 114 WP_001889158.1 hypothetical protein -
K6J78_RS17630 867231..867458 + 228 WP_001894457.1 DUF1289 domain-containing protein -
K6J78_RS17635 867799..868131 + 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin -
K6J78_RS17640 868118..868432 + 315 WP_000071008.1 DNA-binding transcriptional regulator -
K6J78_RS17645 868569..869003 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
K6J78_RS17650 869171..869326 + 156 WP_000751734.1 hypothetical protein -
K6J78_RS17655 869451..870431 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
K6J78_RS17660 870499..870805 + 307 Protein_834 CatB-related O-acetyltransferase -
K6J78_RS18805 870942..871340 + 399 Protein_835 GNAT family N-acetyltransferase -
K6J78_RS18810 871464..871634 + 171 WP_001080654.1 hypothetical protein Antitoxin
K6J78_RS17670 871634..872035 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
K6J78_RS18815 872038..872148 + 111 WP_082798255.1 DUF3265 domain-containing protein -
K6J78_RS17675 872223..872636 + 414 WP_000049417.1 VOC family protein -
K6J78_RS17680 872850..873101 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
K6J78_RS17685 873091..873378 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
K6J78_RS17690 873506..873961 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
K6J78_RS18820 874018..874140 + 123 Protein_843 acetyltransferase -
K6J78_RS17695 874311..874435 + 125 Protein_844 DUF645 family protein -
K6J78_RS18825 874552..874620 + 69 Protein_845 acetyltransferase -
K6J78_RS17700 874637..875134 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
K6J78_RS17705 875131..875403 - 273 WP_000246253.1 DUF1778 domain-containing protein -
K6J78_RS18830 875555..875617 + 63 Protein_848 acetyltransferase -
K6J78_RS17710 875634..876302 + 669 WP_000043871.1 hypothetical protein -
K6J78_RS17715 876454..876741 + 288 WP_000426470.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 782725..888585 105860
flank IS/Tn - - 869451..870431 980
- inside Integron - - 835106..888236 53130


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T38643 WP_000351248.1 NZ_AP024550:871634-872035 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T38643 NZ_AP024550:871634-872035 [Vibrio cholerae]
ATGGATATCATCTGTTTTCCTTTTGAACGAGTGATCGAGATTAATGCTTTCATCCTAAAAACAGAACCAGGAATGAAAGG
AGCCGTTGATATTCCCAAGCTTCAGGGGGCATTAGGTCGAATCGATAATGCCATCGTTTATGAAGGACTGGATGATGTTT
TTGAAATCGCTGCTAAATACACTGCTTGTATAGCGGTTTCACATGCGCTACCTGATGCGAACAAACGCACAGGTTTGGCT
GTGGCACTTGAATATTTATCACTTAACGATTTTGAGCTTACGCAGGAAAACGATTTACTTGCGGATGCAGTTCGAGATCT
TGTTATCGGCATTATCAACGAAACAGATTTTGCCGACATTCTCTACGCACAATACGCAAAAGAACAAAATTCAGCTCTCT
AA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6287.35 Da        Isoelectric Point: 10.7274

>AT38643 WP_001080654.1 NZ_AP024550:871464-871634 [Vibrio cholerae]
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 171 bp

>AT38643 NZ_AP024550:871464-871634 [Vibrio cholerae]
ATGAATCGAAAAGTTGAAGCTTACGGCGTTGATGCTGTTGAAAGACCGAAAATTAAGGCTAGTAAAAAGCTTGATTTGAC
TGGTGATGCTGGTCGTCAAATTGTGAAGTCTGAAACTAAACTTGCTTTGCGTACTCATCAGAAGACATTCACTAAATTGG
CTGATATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0PN34

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SJJ1

References