Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1526597..1527125 Replicon chromosome
Accession NZ_AP018677
Organism Vibrio cholerae strain V060002

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag V060002_RS07410 Protein ID WP_000221354.1
Coordinates 1526597..1526884 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag V060002_RS07415 Protein ID WP_001250179.1
Coordinates 1526874..1527125 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
V060002_RS07360 1521700..1522233 - 534 WP_000118351.1 GNAT family N-acetyltransferase -
V060002_RS19480 1522230..1522655 - 426 WP_001882332.1 DUF1778 domain-containing protein -
V060002_RS07370 1522722..1523093 - 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
V060002_RS07375 1523234..1523521 - 288 WP_000426470.1 hypothetical protein -
V060002_RS07380 1523673..1524341 - 669 WP_000043871.1 hypothetical protein -
V060002_RS07385 1524572..1524844 + 273 WP_000246253.1 DUF1778 domain-containing protein -
V060002_RS07390 1524841..1525338 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
V060002_RS07400 1525540..1525692 - 153 WP_001884520.1 DUF645 family protein -
V060002_RS07405 1526014..1526469 - 456 WP_001245327.1 GNAT family N-acetyltransferase -
V060002_RS07410 1526597..1526884 - 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
V060002_RS07415 1526874..1527125 - 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
V060002_RS07420 1527339..1527752 - 414 WP_000049417.1 VOC family protein -
V060002_RS07425 1527827..1527970 - 144 WP_071908341.1 DUF3265 domain-containing protein -
V060002_RS07430 1527940..1528341 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
V060002_RS07435 1528341..1529033 - 693 WP_001047169.1 GNAT family N-acetyltransferase -
V060002_RS07440 1529170..1529476 - 307 Protein_1375 CatB-related O-acetyltransferase -
V060002_RS07445 1529544..1530524 + 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
V060002_RS19485 1530649..1530804 - 156 WP_000751734.1 hypothetical protein -
V060002_RS07450 1530972..1531406 - 435 WP_000256036.1 GNAT family N-acetyltransferase -
V060002_RS07455 1531543..1531857 - 315 WP_000071008.1 DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 1516275..1622843 106568
flank IS/Tn - - 1529544..1530524 980
- inside Integron - - 1511738..1563819 52081


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T31955 WP_000221354.1 NZ_AP018677:c1526884-1526597 [Vibrio cholerae]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T31955 NZ_AP018677:c1526884-1526597 [Vibrio cholerae]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT31955 WP_001250179.1 NZ_AP018677:c1527125-1526874 [Vibrio cholerae]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT31955 NZ_AP018677:c1527125-1526874 [Vibrio cholerae]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X1KZS6

Antitoxin

Source ID Structure
AlphaFold DB A0A0X1KZS8

References