Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 1524572..1525338 Replicon chromosome
Accession NZ_AP018677
Organism Vibrio cholerae strain V060002

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag V060002_RS07390 Protein ID WP_000982260.1
Coordinates 1524841..1525338 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag V060002_RS07385 Protein ID WP_000246253.1
Coordinates 1524572..1524844 (+) Length 91 a.a.

Genomic Context

V060002_RS07385V060002_RS07390V060002_RS07340V060002_RS07345V060002_RS07350V060002_RS07360V060002_RS19480V060002_RS07370V060002_RS07375V060002_RS07380V060002_RS07400V060002_RS07405V060002_RS07410V060002_RS07415V060002_RS07420V060002_RS07425V060002_RS07430V060002_RS07435V060002_RS07440
Location: 1524572..1524844 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
Location: 1524841..1525338 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 1519800..1520717 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 1520951..1521253 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 1521241..1521498 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 1521700..1522233 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 1522230..1522655 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 1522722..1523093 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 1523234..1523521 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 1523673..1524341 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 1525540..1525692 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 1526014..1526469 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 1526597..1526884 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 1526874..1527125 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 1527339..1527752 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 1527827..1527970 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 1527940..1528341 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 1528341..1529033 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 1529170..1529476 (307 bp)
Type: Others
Protein ID: Protein_1375
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
V060002_RS073401519800..1520717-918WP_000186333.1alpha/beta hydrolase-
V060002_RS073451520951..1521253-303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
V060002_RS073501521241..1521498-258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
V060002_RS073601521700..1522233-534WP_000118351.1GNAT family N-acetyltransferase-
V060002_RS194801522230..1522655-426WP_001882332.1DUF1778 domain-containing protein-
V060002_RS073701522722..1523093-372WP_001164080.1nucleotide pyrophosphohydrolase-
V060002_RS073751523234..1523521-288WP_000426470.1hypothetical protein-
V060002_RS073801523673..1524341-669WP_000043871.1hypothetical protein-
V060002_RS073851524572..1524844+273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
V060002_RS073901524841..1525338+498WP_000982260.1GNAT family N-acetyltransferaseToxin
V060002_RS074001525540..1525692-153WP_001884520.1DUF645 family protein-
V060002_RS074051526014..1526469-456WP_001245327.1GNAT family N-acetyltransferase-
V060002_RS074101526597..1526884-288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
V060002_RS074151526874..1527125-252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
V060002_RS074201527339..1527752-414WP_000049417.1VOC family protein-
V060002_RS074251527827..1527970-144WP_071908341.1DUF3265 domain-containing protein-
V060002_RS074301527940..1528341-402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
V060002_RS074351528341..1529033-693WP_001047169.1GNAT family N-acetyltransferase-
V060002_RS074401529170..1529476-307Protein_1375CatB-related O-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-1516275..1622843106568
flankIS/Tn--1529544..1530524980
-insideIntegron--1511738..156381952081


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T31954 WP_000982260.1 NZ_AP018677:1524841-1525338 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T31954 NZ_AP018677:1524841-1525338 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT31954 WP_000246253.1 NZ_AP018677:1524572-1524844 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT31954 NZ_AP018677:1524572-1524844 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References