31954

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 1524572..1525338 Replicon chromosome
Accession NZ_AP018677
Organism Vibrio cholerae strain V060002

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag V060002_RS07390 Protein ID WP_000982260.1
Coordinates 1524841..1525338 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag V060002_RS07385 Protein ID WP_000246253.1
Coordinates 1524572..1524844 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
V060002_RS07340 1519800..1520717 - 918 WP_000186333.1 alpha/beta hydrolase -
V060002_RS07345 1520951..1521253 - 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin -
V060002_RS07350 1521241..1521498 - 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
V060002_RS07360 1521700..1522233 - 534 WP_000118351.1 GNAT family N-acetyltransferase -
V060002_RS19480 1522230..1522655 - 426 WP_001882332.1 DUF1778 domain-containing protein -
V060002_RS07370 1522722..1523093 - 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
V060002_RS07375 1523234..1523521 - 288 WP_000426470.1 hypothetical protein -
V060002_RS07380 1523673..1524341 - 669 WP_000043871.1 hypothetical protein -
V060002_RS07385 1524572..1524844 + 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
V060002_RS07390 1524841..1525338 + 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
V060002_RS07400 1525540..1525692 - 153 WP_001884520.1 DUF645 family protein -
V060002_RS07405 1526014..1526469 - 456 WP_001245327.1 GNAT family N-acetyltransferase -
V060002_RS07410 1526597..1526884 - 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
V060002_RS07415 1526874..1527125 - 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
V060002_RS07420 1527339..1527752 - 414 WP_000049417.1 VOC family protein -
V060002_RS07425 1527827..1527970 - 144 WP_071908341.1 DUF3265 domain-containing protein -
V060002_RS07430 1527940..1528341 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
V060002_RS07435 1528341..1529033 - 693 WP_001047169.1 GNAT family N-acetyltransferase -
V060002_RS07440 1529170..1529476 - 307 Protein_1375 CatB-related O-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 1516275..1622843 106568
flank IS/Tn - - 1529544..1530524 980
- inside Integron - - 1511738..1563819 52081


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T31954 WP_000982260.1 NZ_AP018677:1524841-1525338 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T31954 NZ_AP018677:1524841-1525338 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT31954 WP_000246253.1 NZ_AP018677:1524572-1524844 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT31954 NZ_AP018677:1524572-1524844 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References