Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) dhiT-phd/-
Location 1515814..1516218 Replicon chromosome
Accession NZ_AP018677
Organism Vibrio cholerae strain V060002

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag V060002_RS07300 Protein ID WP_001114075.1
Coordinates 1515814..1516083 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag V060002_RS07305 Protein ID WP_099607150.1
Coordinates 1516114..1516218 (-) Length 35 a.a.

Genomic Context

V060002_RS07270V060002_RS07275V060002_RS07255V060002_RS07265V060002_RS07280V060002_RS07290V060002_RS07295V060002_RS07300V060002_RS07305V060002_RS07310V060002_RS07315V060002_RS07320V060002_RS07325V060002_RS07330V060002_RS07335V060002_RS07340
Location: 1513531..1513815 (285 bp)
Type: Others
Protein ID: WP_000381183.1
Location: 1513812..1514090 (279 bp)
Type: Others
Protein ID: WP_000578476.1
Location: 1512225..1512638 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 1512822..1513337 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 1514229..1514624 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 1514875..1515000 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 1515299..1515820 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 1515814..1516083 (270 bp)
Type: Toxin
Protein ID: WP_001114075.1
Location: 1516114..1516218 (105 bp)
Type: Antitoxin
Protein ID: WP_099607150.1
Location: 1516275..1516874 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 1517024..1517896 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 1518071..1518289 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 1518353..1518790 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 1518909..1519118 (210 bp)
Type: Others
Protein ID: Protein_1355
Location: 1519254..1519643 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 1519800..1520717 (918 bp)
Type: Others
Protein ID: WP_000186333.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
V060002_RS072551512225..1512638-414WP_000049420.1VOC family protein-
V060002_RS072651512822..1513337-516WP_000343779.1GNAT family N-acetyltransferase-
V060002_RS072701513531..1513815+285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
V060002_RS072751513812..1514090+279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family-
V060002_RS072801514229..1514624-396WP_001000867.1hypothetical protein-
V060002_RS072901514875..1515000-126WP_001905700.1DUF645 family protein-
V060002_RS072951515299..1515820-522WP_000921691.1DUF2442 domain-containing protein-
V060002_RS073001515814..1516083-270WP_001114075.1DUF4160 domain-containing proteinToxin
V060002_RS073051516114..1516218-105WP_099607150.1acetyltransferaseAntitoxin
V060002_RS073101516275..1516874-600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
V060002_RS073151517024..1517896-873WP_000254716.1DUF3800 domain-containing protein-
V060002_RS073201518071..1518289-219WP_071908318.1GNAT family N-acetyltransferase-
V060002_RS073251518353..1518790-438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
V060002_RS073301518909..1519118-210Protein_1355GNAT family N-acetyltransferase-
V060002_RS073351519254..1519643-390WP_001081302.1hypothetical protein-
V060002_RS073401519800..1520717-918WP_000186333.1alpha/beta hydrolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-1516275..1622843106568
flankIS/Tn--1518353..1518790437
-insideIntegron--1511738..156381952081


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T31951 WP_001114075.1 NZ_AP018677:c1516083-1515814 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T31951 NZ_AP018677:c1516083-1515814 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 35 a.a.        Molecular weight: 3991.79 Da        Isoelectric Point: 9.2853

>AT31951 WP_099607150.1 NZ_AP018677:c1516218-1516114 [Vibrio cholerae]
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL

Download         Length: 105 bp

>AT31951 NZ_AP018677:c1516218-1516114 [Vibrio cholerae]
GTGGTTTCGGTTGTTGTGTTTGAGTTTAGTAGTATGCGCTGCCAGCCCCTTAGGCGGGCGTTATATGCTTATAGGAATTG
TCTCCTAAAGGATACGCTGCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A086SLD6

Antitoxin

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Source
ID
Structure
No matching records found

References