31950

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 1515299..1516083 Replicon chromosome
Accession NZ_AP018677
Organism Vibrio cholerae strain V060002

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag V060002_RS07300 Protein ID WP_001114075.1
Coordinates 1515814..1516083 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag V060002_RS07295 Protein ID WP_000921691.1
Coordinates 1515299..1515820 (-) Length 174 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
V060002_RS07255 1512225..1512638 - 414 WP_000049420.1 VOC family protein -
V060002_RS07265 1512822..1513337 - 516 WP_000343779.1 GNAT family N-acetyltransferase -
V060002_RS07270 1513531..1513815 + 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
V060002_RS07275 1513812..1514090 + 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
V060002_RS07280 1514229..1514624 - 396 WP_001000867.1 hypothetical protein -
V060002_RS07290 1514875..1515000 - 126 WP_001905700.1 DUF645 family protein -
V060002_RS07295 1515299..1515820 - 522 WP_000921691.1 DUF2442 domain-containing protein Antitoxin
V060002_RS07300 1515814..1516083 - 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
V060002_RS07305 1516114..1516218 - 105 WP_099607150.1 acetyltransferase -
V060002_RS07310 1516275..1516874 - 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
V060002_RS07315 1517024..1517896 - 873 WP_000254716.1 DUF3800 domain-containing protein -
V060002_RS07320 1518071..1518289 - 219 WP_071908318.1 GNAT family N-acetyltransferase -
V060002_RS07325 1518353..1518790 - 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
V060002_RS07330 1518909..1519118 - 210 Protein_1355 GNAT family N-acetyltransferase -
V060002_RS07335 1519254..1519643 - 390 WP_001081302.1 hypothetical protein -
V060002_RS07340 1519800..1520717 - 918 WP_000186333.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 1516275..1622843 106568
flank IS/Tn - - 1518353..1518790 437
- inside Integron - - 1511738..1563819 52081


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T31950 WP_001114075.1 NZ_AP018677:c1516083-1515814 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T31950 NZ_AP018677:c1516083-1515814 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT31950 WP_000921691.1 NZ_AP018677:c1515820-1515299 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT31950 NZ_AP018677:c1515820-1515299 [Vibrio cholerae]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAGCACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure
AlphaFold DB Q9KM84

References