31949

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1513531..1514090 Replicon chromosome
Accession NZ_AP018677
Organism Vibrio cholerae strain V060002

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag V060002_RS07275 Protein ID WP_000578476.1
Coordinates 1513812..1514090 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag V060002_RS07270 Protein ID WP_000381183.1
Coordinates 1513531..1513815 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
V060002_RS07255 1512225..1512638 - 414 WP_000049420.1 VOC family protein -
V060002_RS07265 1512822..1513337 - 516 WP_000343779.1 GNAT family N-acetyltransferase -
V060002_RS07270 1513531..1513815 + 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
V060002_RS07275 1513812..1514090 + 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
V060002_RS07280 1514229..1514624 - 396 WP_001000867.1 hypothetical protein -
V060002_RS07290 1514875..1515000 - 126 WP_001905700.1 DUF645 family protein -
V060002_RS07295 1515299..1515820 - 522 WP_000921691.1 DUF2442 domain-containing protein -
V060002_RS07300 1515814..1516083 - 270 WP_001114075.1 DUF4160 domain-containing protein -
V060002_RS07305 1516114..1516218 - 105 WP_099607150.1 acetyltransferase -
V060002_RS07310 1516275..1516874 - 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
V060002_RS07315 1517024..1517896 - 873 WP_000254716.1 DUF3800 domain-containing protein -
V060002_RS07320 1518071..1518289 - 219 WP_071908318.1 GNAT family N-acetyltransferase -
V060002_RS07325 1518353..1518790 - 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 1516275..1622843 106568
flank IS/Tn - - 1518353..1518790 437
- inside Integron - - 1511738..1563819 52081


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T31949 WP_000578476.1 NZ_AP018677:1513812-1514090 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T31949 NZ_AP018677:1513812-1514090 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT31949 WP_000381183.1 NZ_AP018677:1513531-1513815 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT31949 NZ_AP018677:1513531-1513815 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References