Detailed information of TA system TA030648

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-Phd
• Location: 435445..435992
• Replicon: chromosome
• Accession: NZ_AP014525
• Organism: Vibrio cholerae MS6

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q9KM92
• Locus tag: MS6_RS15880
• Protein ID: WP_000229317.1
• Coordinates: 435690..435992 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9KM93
• Locus tag: MS6_RS15875
• Protein ID: WP_000861987.1
• Coordinates: 435445..435702 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MS6_RS15830	430821..431072	+	252	WP_001250179.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
MS6_RS15835	431062..431349	+	288	WP_000221354.1	type II toxin-antitoxin system RelE/ParE family toxin	-
MS6_RS15840	431477..431932	+	456	WP_001245327.1	GNAT family N-acetyltransferase	-
MS6_RS15845	432254..432406	+	153	WP_001884520.1	DUF645 family protein	-
MS6_RS15850	432602..433270	+	669	WP_000043871.1	hypothetical protein	-
MS6_RS15855	433422..433709	+	288	WP_000426470.1	hypothetical protein	-
MS6_RS15860	433850..434221	+	372	WP_001164080.1	nucleotide pyrophosphohydrolase	-
MS6_RS20450	434288..434713	+	426	WP_001882332.1	DUF1778 domain-containing protein	-
MS6_RS15870	434710..435243	+	534	WP_000118351.1	GNAT family N-acetyltransferase	-
MS6_RS15875	435445..435702	+	258	WP_000861987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MS6_RS15880	435690..435992	+	303	WP_000229317.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MS6_RS15885	436226..437143	+	918	WP_000186333.1	alpha/beta hydrolase	-
MS6_RS15890	437300..437689	+	390	WP_001081302.1	hypothetical protein	-
MS6_RS15895	437825..438034	+	210	Protein_483	GNAT family N-acetyltransferase	-
MS6_RS15900	438153..438590	+	438	WP_041051975.1	IS200/IS605 family transposase	-
MS6_RS15905	438654..438872	+	219	WP_071908318.1	GNAT family N-acetyltransferase	-
MS6_RS15910	439047..439919	+	873	WP_000254716.1	DUF3800 domain-containing protein	-
MS6_RS15915	440069..440668	+	600	WP_001891245.1	glutathione S-transferase N-terminal domain-containing protein	-
MS6_RS20255	440725..440829	+	105	WP_099607150.1	acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	qnrVC4	-	297729..445581	147852
	-	inside	Integron	qnrVC4	-	302809..445205	142396
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 IS/Tn TA000179, TA000177, TA000178, TA010035 428335..428772 0.002	flank	IS/Tn	-	-	438153..438590	437

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11726.68 Da
• Isoelectric Point: 5.1972

>T30648 WP_000229317.1 NZ_AP014525:435690-435992 [Vibrio cholerae MS6]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Nucleotide

• Length: 303 bp

>T30648 NZ_AP014525:435690-435992 [Vibrio cholerae MS6]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9647.15 Da
• Isoelectric Point: 7.3178

>AT30648 WP_000861987.1 NZ_AP014525:435445-435702 [Vibrio cholerae MS6]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Nucleotide

• Length: 258 bp

>AT30648 NZ_AP014525:435445-435702 [Vibrio cholerae MS6]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Structures

Toxin

• AlphaFold DB: Q9KM92

Antitoxin

• AlphaFold DB: A0A1T4SLM9