Detailed information of TA system TA295404

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 165403..167078
• Replicon: chromosome
• Accession: NZ_OW443150
• Organism: Vibrio cholerae strain CNRVC190247 isolate YE-NCPHL-18035-PI

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: OC536_RS00795
• Protein ID: WP_032477282.1
• Coordinates: 165867..167078 (+)
• Length: 404 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: A0A0X8LPP8
• Locus tag: OC536_RS00790
• Protein ID: WP_000649312.1
• Coordinates: 165403..165870 (+)
• Length: 156 a.a.

Genomic Context

Location: 162600..163085 (486 bp)
Type: Others
Protein ID: WP_237733639.1

Location: 163082..164446 (1365 bp)
Type: Others
Protein ID: WP_032477283.1

Location: 164446..165213 (768 bp)
Type: Others
Protein ID: WP_000230362.1

Location: 165403..165870 (468 bp)
Type: Antitoxin
Protein ID: WP_000649312.1

Location: 165867..167078 (1212 bp)
Type: Toxin
Protein ID: WP_032477282.1

Location: 168829..170664 (1836 bp)
Type: Others
Protein ID: WP_032477280.1

Location: 170840..171277 (438 bp)
Type: Others
Protein ID: WP_000503164.1

Location: 167322..168431 (1110 bp)
Type: Others
Protein ID: WP_032477281.1

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Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OC536_RS00775	162600..163085	+	486	WP_237733639.1	hypothetical protein	-
OC536_RS00780 (CNRVC190247_00159)	163082..164446	+	1365	WP_032477283.1	hypothetical protein	-
OC536_RS00785 (CNRVC190247_00160)	164446..165213	+	768	WP_000230362.1	TatD family hydrolase	-
OC536_RS00790 (CNRVC190247_00161)	165403..165870	+	468	WP_000649312.1	DUF4065 domain-containing protein	Antitoxin
OC536_RS00795 (CNRVC190247_00162)	165867..167078	+	1212	WP_032477282.1	RelA/SpoT domain-containing protein	Toxin
OC536_RS00800 (CNRVC190247_00163)	167322..168431	-	1110	WP_032477281.1	tRNA (uridine(54)-C5)-methyltransferase TrmA	-
OC536_RS00805 (CNRVC190247_00164)	168829..170664	+	1836	WP_032477280.1	TonB-dependent vitamin B12 receptor	-
OC536_RS00810 (CNRVC190247_00165)	170840..171277	+	438	WP_000503164.1	IS200/IS605-like element IS1004 family transposase	-

Associated MGEs

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MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 IS/Tn TA000179, TA000177, TA000178, TA010035 428335..428772 0.005	flank	IS/Tn	-	-	170840..171277	437

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RelA/SpoT (86-226)

Antitoxin

• Antitoxin SocA-like, Panacea domain (32-123)

Sequences

Toxin

Protein

• Length: 404 a.a.
• Molecular weight: 45851.69 Da
• Isoelectric Point: 5.2762

>T295404 WP_032477282.1 NZ_OW443150:165867-167078 [Vibrio cholerae]
VSDKEKRVVSFQIDDTPTAEQASKNFQDDYELCFQDFLERTVDESAAEDFSYTNNGVKKAGRRLRKKEGDLKSATATIQQ
FRAAHEKPLNTIAYLVGRCCRELGIDVKPVTRLKRLETIVDKLQRKSLDGETTNATCVTNMNDIGGCRAIFPDLESLEKA
KERLQVTVEKVGRIKIKDIDDYITNPKPNDCGYRSLHVIYRYDHASGKSFNIEAQLRTRLQHLWATTVEIVDILEGTKIK
THSHSPDEDKEKLQVQWEELLSIMSQYIADAEGAIELSNDNRTQFSNRLIELNREINALSRLRSFKILSEKVEGCRDGSI
EHVLLVIDETSLEMIFSEEFENYTQAISVYNAAEKMTRSHARLNTLLISTKNMGQLSEAYPNYLGDCASFITLLEDAMQS
GQN

Nucleotide

• Length: 1212 bp

Antitoxin

Protein

• Length: 156 a.a.
• Molecular weight: 17581.02 Da
• Isoelectric Point: 7.5659

>AT295404 WP_000649312.1 NZ_OW443150:165403-165870 [Vibrio cholerae]
MKAYHTYSAVDVAWSLLKHAKEQGKCFSNLQLQKLTYVCHGLSLAHFQRPLVVDDVFAWKFGPVVPSVYFRFKSYGSNVI
TEQCDVVLDHESESIVKDVVSQLGHLTGPQLVDLTHREGSPWHQVWDGTHQKVIPDHLIQAHYTQIKQSGRTASL

Nucleotide

• Length: 468 bp

Similar Proteins

Only experimentally validated proteins are listed.

Toxin

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Protein	Organism	Identities (%)	Coverage (%)	Ha-value
No matching records found

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Antitoxin

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Protein	Organism	Identities (%)	Coverage (%)	Ha-value
No matching records found

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Structures

Toxin

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Source	ID	Structure
No matching records found

Antitoxin

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• AlphaFold DB: A0A0X8LPP8