295404

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 165403..167078 Replicon chromosome
Accession NZ_OW443150
Organism Vibrio cholerae strain CNRVC190247 isolate YE-NCPHL-18035-PI

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag OC536_RS00795 Protein ID WP_032477282.1
Coordinates 165867..167078 (+) Length 404 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A0X8LPP8
Locus tag OC536_RS00790 Protein ID WP_000649312.1
Coordinates 165403..165870 (+) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OC536_RS00775 162600..163085 + 486 WP_237733639.1 hypothetical protein -
OC536_RS00780 (CNRVC190247_00159) 163082..164446 + 1365 WP_032477283.1 hypothetical protein -
OC536_RS00785 (CNRVC190247_00160) 164446..165213 + 768 WP_000230362.1 TatD family hydrolase -
OC536_RS00790 (CNRVC190247_00161) 165403..165870 + 468 WP_000649312.1 DUF4065 domain-containing protein Antitoxin
OC536_RS00795 (CNRVC190247_00162) 165867..167078 + 1212 WP_032477282.1 RelA/SpoT domain-containing protein Toxin
OC536_RS00800 (CNRVC190247_00163) 167322..168431 - 1110 WP_032477281.1 tRNA (uridine(54)-C5)-methyltransferase TrmA -
OC536_RS00805 (CNRVC190247_00164) 168829..170664 + 1836 WP_032477280.1 TonB-dependent vitamin B12 receptor -
OC536_RS00810 (CNRVC190247_00165) 170840..171277 + 438 WP_000503164.1 IS200/IS605-like element IS1004 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 170840..171277 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(86-226)

Antitoxin

Antitoxin SocA-like, Panacea domain

(32-123)


Sequences

Toxin        


Download         Length: 404 a.a.        Molecular weight: 45851.69 Da        Isoelectric Point: 5.2762

>T295404 WP_032477282.1 NZ_OW443150:165867-167078 [Vibrio cholerae]
VSDKEKRVVSFQIDDTPTAEQASKNFQDDYELCFQDFLERTVDESAAEDFSYTNNGVKKAGRRLRKKEGDLKSATATIQQ
FRAAHEKPLNTIAYLVGRCCRELGIDVKPVTRLKRLETIVDKLQRKSLDGETTNATCVTNMNDIGGCRAIFPDLESLEKA
KERLQVTVEKVGRIKIKDIDDYITNPKPNDCGYRSLHVIYRYDHASGKSFNIEAQLRTRLQHLWATTVEIVDILEGTKIK
THSHSPDEDKEKLQVQWEELLSIMSQYIADAEGAIELSNDNRTQFSNRLIELNREINALSRLRSFKILSEKVEGCRDGSI
EHVLLVIDETSLEMIFSEEFENYTQAISVYNAAEKMTRSHARLNTLLISTKNMGQLSEAYPNYLGDCASFITLLEDAMQS
GQN

Download         Length: 1212 bp

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17581.02 Da        Isoelectric Point: 7.5659

>AT295404 WP_000649312.1 NZ_OW443150:165403-165870 [Vibrio cholerae]
MKAYHTYSAVDVAWSLLKHAKEQGKCFSNLQLQKLTYVCHGLSLAHFQRPLVVDDVFAWKFGPVVPSVYFRFKSYGSNVI
TEQCDVVLDHESESIVKDVVSQLGHLTGPQLVDLTHREGSPWHQVWDGTHQKVIPDHLIQAHYTQIKQSGRTASL

Download         Length: 468 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0X8LPP8

References