293114

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 1745010..1745495 Replicon chromosome
Accession NZ_LT220504
Organism Lacticaseibacillus rhamnosus strain BPL5

Toxin (Protein)


Gene name yafQ Uniprot ID C2K0Y1
Locus tag BN3853_RS14865 Protein ID WP_005691636.1
Coordinates 1745310..1745495 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A508YYT1
Locus tag BN3853_RS08180 Protein ID WP_014571130.1
Coordinates 1745010..1745282 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN3853_RS08155 1740951..1741547 - 597 WP_005691643.1 IS607 family transposase -
BN3853_RS08160 1741690..1742265 - 576 WP_014571131.1 DNA-3-methyladenine glycosylase I -
BN3853_RS08165 1742419..1743582 - 1164 WP_005691640.1 MFS transporter -
BN3853_RS08170 1743664..1743957 - 294 WP_005684269.1 metalloregulator ArsR/SmtB family transcription factor -
BN3853_RS08175 1744200..1744448 - 249 WP_005691639.1 hypothetical protein -
BN3853_RS08180 1745010..1745282 + 273 WP_014571130.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BN3853_RS14865 1745310..1745495 + 186 WP_005691636.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
BN3853_RS08185 1745719..1747134 + 1416 WP_005691634.1 DNA polymerase III subunit epsilon -
BN3853_RS08190 1747377..1748252 - 876 WP_024305787.1 XRE family transcriptional regulator -
BN3853_RS08200 1748699..1749307 + 609 WP_005691630.1 hypothetical protein -
BN3853_RS08205 1749799..1750488 - 690 WP_005691628.1 rhomboid family intramembrane serine protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1739484..1750488 11004


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-57)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-65)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6781.86 Da        Isoelectric Point: 7.4698

>T293114 WP_005691636.1 NZ_LT220504:1745310-1745495 [Lacticaseibacillus rhamnosus]
MQRQGHVKLASLHDHALKGAHSGERALRVAPDWLLVYKVDAEALILMLLATGTHRDTLNIE

Download         Length: 186 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10005.62 Da        Isoelectric Point: 9.5939

>AT293114 WP_014571130.1 NZ_LT220504:1745010-1745282 [Lacticaseibacillus rhamnosus]
MTKKSRISVRIDTKTKERALHVLNSMGLDISSAINMYLKRIGDTGALPFTPPMSFVDQLQVAEADVKAGRIKSFKTVDAL
MKDLYSDVDD

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7X2J6C9

Antitoxin

Source ID Structure
AlphaFold DB A0A508YYT1

References