Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 1362453..1362824 Replicon chromosome
Accession NZ_LM995446
Organism Escherichia coli strain K-12 substr. RV308

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag ECRV308_RS06835 Protein ID WP_001317028.1
Coordinates 1362630..1362824 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 1362453..1362631 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECRV308_RS06810 1358408..1359781 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
ECRV308_RS06815 1359910..1360845 - 936 WP_001157406.1 tRNA 2-thiocytidine(32) synthetase TtcA -
ECRV308_RS23415 1360897..1362132 - 1236 WP_000040852.1 site-specific integrase -
ECRV308_RS06825 1362134..1362349 - 216 WP_000079604.1 excisionase XisR -
ECRV308_RS06830 1362428..1362637 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
- 1362453..1362631 + 179 NuclAT_0 - Antitoxin
- 1362453..1362631 + 179 NuclAT_0 - Antitoxin
- 1362453..1362631 + 179 NuclAT_0 - Antitoxin
- 1362453..1362631 + 179 NuclAT_0 - Antitoxin
ECRV308_RS06835 1362630..1362824 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
ECRV308_RS06840 1362881..1363690 - 810 WP_000166319.1 recombination protein RecT -
ECRV308_RS06845 1363683..1366283 - 2601 WP_000105143.1 exodeoxyribonuclease VIII -
ECRV308_RS06850 1366385..1366660 - 276 WP_000632297.1 protein RacC -
ECRV308_RS06855 1366735..1366905 - 171 WP_001352098.1 conserved protein, Rac prophage -
ECRV308_RS06860 1366905..1367126 - 222 WP_000560225.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1360897..1382571 21674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T285430 WP_001317028.1 NZ_LM995446:c1362824-1362630 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

Antitoxin


Download         Length: 179 bp

>AT285430 NZ_LM995446:1362453-1362631 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References