Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 1035923..1036294 Replicon chromosome
Accession NZ_CP128218
Organism Escherichia coli strain TG1

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag QSI84_RS05175 Protein ID WP_001317028.1
Coordinates 1036100..1036294 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 1035923..1036101 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSI84_RS05145 (1031675) 1031675..1031848 + 174 WP_001296046.1 protein YnaL -
QSI84_RS05150 (1031878) 1031878..1033251 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
QSI84_RS05155 (1033380) 1033380..1034315 - 936 WP_001157406.1 tRNA 2-thiocytidine(32) synthetase TtcA -
QSI84_RS05160 (1034367) 1034367..1035602 - 1236 WP_000040852.1 site-specific integrase -
QSI84_RS05165 (1035604) 1035604..1035819 - 216 WP_000079604.1 excisionase XisR -
- (1035923) 1035923..1036101 + 179 NuclAT_0 - Antitoxin
- (1035923) 1035923..1036101 + 179 NuclAT_0 - Antitoxin
- (1035923) 1035923..1036101 + 179 NuclAT_0 - Antitoxin
- (1035923) 1035923..1036101 + 179 NuclAT_0 - Antitoxin
QSI84_RS05170 (1035898) 1035898..1036107 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
QSI84_RS05175 (1036100) 1036100..1036294 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
QSI84_RS05180 (1036351) 1036351..1037160 - 810 WP_000166319.1 recombination protein RecT -
QSI84_RS05185 (1037153) 1037153..1039753 - 2601 WP_000105143.1 exodeoxyribonuclease VIII -
QSI84_RS05190 (1039855) 1039855..1040130 - 276 WP_000632297.1 protein RacC -
QSI84_RS05195 (1040205) 1040205..1040375 - 171 WP_001352098.1 YdaE family protein -
QSI84_RS05200 (1040375) 1040375..1040596 - 222 WP_000560225.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1034367..1056041 21674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T284412 WP_001317028.1 NZ_CP128218:c1036294-1036100 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

Antitoxin


Download         Length: 179 bp

>AT284412 NZ_CP128218:1035923-1036101 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References