Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 3849407..3849778 Replicon chromosome
Accession NZ_CP122319
Organism Escherichia coli strain BW25113

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag QCG47_RS18685 Protein ID WP_001317028.1
Coordinates 3849584..3849778 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 3849407..3849585 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG47_RS18655 (3845159) 3845159..3845332 + 174 WP_001296046.1 protein YnaL -
QCG47_RS18660 (3845362) 3845362..3846735 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
QCG47_RS18665 (3846864) 3846864..3847799 - 936 WP_001157406.1 tRNA 2-thiocytidine(32) synthetase TtcA -
QCG47_RS18670 (3847851) 3847851..3849086 - 1236 WP_000040852.1 site-specific integrase -
QCG47_RS18675 (3849088) 3849088..3849303 - 216 WP_000079604.1 excisionase XisR -
- (3849407) 3849407..3849585 + 179 NuclAT_0 - Antitoxin
- (3849407) 3849407..3849585 + 179 NuclAT_0 - Antitoxin
- (3849407) 3849407..3849585 + 179 NuclAT_0 - Antitoxin
- (3849407) 3849407..3849585 + 179 NuclAT_0 - Antitoxin
QCG47_RS18680 (3849382) 3849382..3849591 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
QCG47_RS18685 (3849584) 3849584..3849778 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
QCG47_RS18690 (3849835) 3849835..3850644 - 810 WP_000166319.1 recombination protein RecT -
QCG47_RS18695 (3850637) 3850637..3853237 - 2601 WP_000105143.1 exodeoxyribonuclease VIII -
QCG47_RS18700 (3853339) 3853339..3853614 - 276 WP_000632297.1 protein RacC -
QCG47_RS18705 (3853689) 3853689..3853859 - 171 WP_001352098.1 YdaE family protein -
QCG47_RS18710 (3853859) 3853859..3854080 - 222 WP_000560225.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 3847851..3869525 21674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T276772 WP_001317028.1 NZ_CP122319:c3849778-3849584 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

Antitoxin


Download         Length: 179 bp

>AT276772 NZ_CP122319:3849407-3849585 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References