Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 4550851..4551222 Replicon chromosome
Accession NZ_CP122317
Organism Escherichia coli strain HT-948

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag QCG49_RS22240 Protein ID WP_001317028.1
Coordinates 4551028..4551222 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 4550851..4551029 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG49_RS22210 (4546603) 4546603..4546776 + 174 WP_001296046.1 protein YnaL -
QCG49_RS22215 (4546806) 4546806..4548179 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
QCG49_RS22220 (4548308) 4548308..4549243 - 936 WP_001157406.1 tRNA 2-thiocytidine(32) synthetase TtcA -
QCG49_RS22225 (4549295) 4549295..4550530 - 1236 WP_000040852.1 site-specific integrase -
QCG49_RS22230 (4550532) 4550532..4550747 - 216 WP_000079604.1 excisionase XisR -
- (4550851) 4550851..4551029 + 179 NuclAT_0 - Antitoxin
- (4550851) 4550851..4551029 + 179 NuclAT_0 - Antitoxin
- (4550851) 4550851..4551029 + 179 NuclAT_0 - Antitoxin
- (4550851) 4550851..4551029 + 179 NuclAT_0 - Antitoxin
QCG49_RS22235 (4550826) 4550826..4551035 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
QCG49_RS22240 (4551028) 4551028..4551222 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
QCG49_RS22245 (4551279) 4551279..4552088 - 810 WP_000166319.1 recombination protein RecT -
QCG49_RS22250 (4552081) 4552081..4554681 - 2601 WP_000105143.1 exodeoxyribonuclease VIII -
QCG49_RS22255 (4554783) 4554783..4555058 - 276 WP_000632297.1 protein RacC -
QCG49_RS22260 (4555133) 4555133..4555303 - 171 WP_001352098.1 YdaE family protein -
QCG49_RS22265 (4555303) 4555303..4555524 - 222 WP_000560225.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 4549295..4570969 21674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T276717 WP_001317028.1 NZ_CP122317:c4551222-4551028 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

Antitoxin


Download         Length: 179 bp

>AT276717 NZ_CP122317:4550851-4551029 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References