Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 2825006..2825377 Replicon chromosome
Accession NZ_CP122315
Organism Escherichia coli strain HT-947

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag QCG46_RS13885 Protein ID WP_001317028.1
Coordinates 2825183..2825377 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 2825006..2825184 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG46_RS13855 (2820758) 2820758..2820931 + 174 WP_001296046.1 protein YnaL -
QCG46_RS13860 (2820961) 2820961..2822334 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
QCG46_RS13865 (2822463) 2822463..2823398 - 936 WP_001157406.1 tRNA 2-thiocytidine(32) synthetase TtcA -
QCG46_RS13870 (2823450) 2823450..2824685 - 1236 WP_000040852.1 site-specific integrase -
QCG46_RS13875 (2824687) 2824687..2824902 - 216 WP_000079604.1 excisionase XisR -
- (2825006) 2825006..2825184 + 179 NuclAT_0 - Antitoxin
- (2825006) 2825006..2825184 + 179 NuclAT_0 - Antitoxin
- (2825006) 2825006..2825184 + 179 NuclAT_0 - Antitoxin
- (2825006) 2825006..2825184 + 179 NuclAT_0 - Antitoxin
QCG46_RS13880 (2824981) 2824981..2825190 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
QCG46_RS13885 (2825183) 2825183..2825377 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
QCG46_RS13890 (2825434) 2825434..2826243 - 810 WP_000166319.1 recombination protein RecT -
QCG46_RS13895 (2826236) 2826236..2828836 - 2601 WP_000105143.1 exodeoxyribonuclease VIII -
QCG46_RS13900 (2828938) 2828938..2829213 - 276 WP_000632297.1 protein RacC -
QCG46_RS13905 (2829288) 2829288..2829458 - 171 WP_001352098.1 YdaE family protein -
QCG46_RS13910 (2829458) 2829458..2829679 - 222 WP_000560225.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2816191..2845124 28933


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T276642 WP_001317028.1 NZ_CP122315:c2825377-2825183 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

Antitoxin


Download         Length: 179 bp

>AT276642 NZ_CP122315:2825006-2825184 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References