275388

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 331475..331960 Replicon chromosome
Accession NZ_CP120736
Organism Lacticaseibacillus rhamnosus strain A5

Toxin (Protein)


Gene name yafQ Uniprot ID C2K0Y1
Locus tag P4692_RS01675 Protein ID WP_005691636.1
Coordinates 331775..331960 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A508YYT1
Locus tag P4692_RS01670 Protein ID WP_014571130.1
Coordinates 331475..331747 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4692_RS01645 327412..328012 - 601 Protein_290 IS607 family transposase -
P4692_RS01650 328155..328730 - 576 WP_014571131.1 DNA-3-methyladenine glycosylase I -
P4692_RS01655 328884..330047 - 1164 WP_277754958.1 MFS transporter -
P4692_RS01660 330129..330422 - 294 WP_005684269.1 metalloregulator ArsR/SmtB family transcription factor -
P4692_RS01665 330665..330913 - 249 WP_005691639.1 hypothetical protein -
P4692_RS01670 331475..331747 + 273 WP_014571130.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
P4692_RS01675 331775..331960 + 186 WP_005691636.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
P4692_RS01680 332184..333599 + 1416 WP_277754959.1 exonuclease domain-containing protein -
P4692_RS01685 333842..334717 - 876 WP_025014074.1 Rgg/GadR/MutR family transcriptional regulator -
P4692_RS01690 335164..335772 + 609 WP_005691630.1 hypothetical protein -
P4692_RS01695 336264..336953 - 690 WP_005691628.1 rhomboid family intramembrane serine protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 325746..336953 11207


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-57)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-65)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6781.86 Da        Isoelectric Point: 7.4698

>T275388 WP_005691636.1 NZ_CP120736:331775-331960 [Lacticaseibacillus rhamnosus]
MQRQGHVKLASLHDHALKGAHSGERALRVAPDWLLVYKVDAEALILMLLATGTHRDTLNIE

Download         Length: 186 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10005.62 Da        Isoelectric Point: 9.5939

>AT275388 WP_014571130.1 NZ_CP120736:331475-331747 [Lacticaseibacillus rhamnosus]
MTKKSRISVRIDTKTKERALHVLNSMGLDISSAINMYLKRIGDTGALPFTPPMSFVDQLQVAEADVKAGRIKSFKTVDAL
MKDLYSDVDD

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7X2J6C9

Antitoxin

Source ID Structure
AlphaFold DB A0A508YYT1

References