272725

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 518053..518538 Replicon chromosome
Accession NZ_CP118050
Organism Lacticaseibacillus rhamnosus strain VSI43

Toxin (Protein)


Gene name yafQ Uniprot ID C2K0Y1
Locus tag PUW66_RS02455 Protein ID WP_005691636.1
Coordinates 518053..518238 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A508YYT1
Locus tag PUW66_RS02460 Protein ID WP_014571130.1
Coordinates 518266..518538 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUW66_RS02435 (PUW66_02435) 513060..513749 + 690 WP_005691628.1 rhomboid family intramembrane serine protease -
PUW66_RS02440 (PUW66_02440) 514241..514849 - 609 WP_005691630.1 hypothetical protein -
PUW66_RS02445 (PUW66_02445) 515296..516171 + 876 WP_024305787.1 XRE family transcriptional regulator -
PUW66_RS02450 (PUW66_02450) 516414..517829 - 1416 WP_005691634.1 exonuclease domain-containing protein -
PUW66_RS02455 (PUW66_02455) 518053..518238 - 186 WP_005691636.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
PUW66_RS02460 (PUW66_02460) 518266..518538 - 273 WP_014571130.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PUW66_RS02465 (PUW66_02465) 519100..519348 + 249 WP_005691639.1 hypothetical protein -
PUW66_RS02470 (PUW66_02470) 519591..519884 + 294 WP_005684269.1 metalloregulator ArsR/SmtB family transcription factor -
PUW66_RS02475 (PUW66_02475) 519966..521129 + 1164 WP_005691640.1 MFS transporter -
PUW66_RS02480 (PUW66_02480) 521283..521858 + 576 WP_014571131.1 DNA-3-methyladenine glycosylase I -
PUW66_RS02485 (PUW66_02485) 522001..522597 + 597 WP_005691643.1 IS607 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 513060..524263 11203
inside Genomic island - - 513060..525273 12213


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-57)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-65)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6781.86 Da        Isoelectric Point: 7.4698

>T272725 WP_005691636.1 NZ_CP118050:c518238-518053 [Lacticaseibacillus rhamnosus]
MQRQGHVKLASLHDHALKGAHSGERALRVAPDWLLVYKVDAEALILMLLATGTHRDTLNIE

Download         Length: 186 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10005.62 Da        Isoelectric Point: 9.5939

>AT272725 WP_014571130.1 NZ_CP118050:c518538-518266 [Lacticaseibacillus rhamnosus]
MTKKSRISVRIDTKTKERALHVLNSMGLDISSAINMYLKRIGDTGALPFTPPMSFVDQLQVAEADVKAGRIKSFKTVDAL
MKDLYSDVDD

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7X2J6C9

Antitoxin

Source ID Structure
AlphaFold DB A0A508YYT1

References