272698

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 521493..521978 Replicon chromosome
Accession NZ_CP118035
Organism Lacticaseibacillus rhamnosus strain VSI33

Toxin (Protein)


Gene name yafQ Uniprot ID C2K0Y1
Locus tag PUW67_RS02470 Protein ID WP_005691636.1
Coordinates 521493..521678 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A508YYT1
Locus tag PUW67_RS02475 Protein ID WP_014571130.1
Coordinates 521706..521978 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUW67_RS02450 (PUW67_02450) 516500..517189 + 690 WP_005691628.1 rhomboid family intramembrane serine protease -
PUW67_RS02455 (PUW67_02455) 517681..518289 - 609 WP_005691630.1 hypothetical protein -
PUW67_RS02460 (PUW67_02460) 518736..519611 + 876 WP_025014074.1 Rgg/GadR/MutR family transcriptional regulator -
PUW67_RS02465 (PUW67_02465) 519854..521269 - 1416 WP_005691634.1 exonuclease domain-containing protein -
PUW67_RS02470 (PUW67_02470) 521493..521678 - 186 WP_005691636.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
PUW67_RS02475 (PUW67_02475) 521706..521978 - 273 WP_014571130.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PUW67_RS02480 (PUW67_02480) 522540..522788 + 249 WP_005691639.1 hypothetical protein -
PUW67_RS02485 (PUW67_02485) 523031..523324 + 294 WP_005684269.1 metalloregulator ArsR/SmtB family transcription factor -
PUW67_RS02490 (PUW67_02490) 523406..524569 + 1164 WP_005691640.1 MFS transporter -
PUW67_RS02495 (PUW67_02495) 524723..525298 + 576 WP_014571131.1 DNA-3-methyladenine glycosylase I -
PUW67_RS02500 (PUW67_02500) 525441..526037 + 597 WP_005691643.1 IS607 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 517681..527703 10022


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-57)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-65)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6781.86 Da        Isoelectric Point: 7.4698

>T272698 WP_005691636.1 NZ_CP118035:c521678-521493 [Lacticaseibacillus rhamnosus]
MQRQGHVKLASLHDHALKGAHSGERALRVAPDWLLVYKVDAEALILMLLATGTHRDTLNIE

Download         Length: 186 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10005.62 Da        Isoelectric Point: 9.5939

>AT272698 WP_014571130.1 NZ_CP118035:c521978-521706 [Lacticaseibacillus rhamnosus]
MTKKSRISVRIDTKTKERALHVLNSMGLDISSAINMYLKRIGDTGALPFTPPMSFVDQLQVAEADVKAGRIKSFKTVDAL
MKDLYSDVDD

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7X2J6C9

Antitoxin

Source ID Structure
AlphaFold DB A0A508YYT1

References